Serine/threonine-protein Phosphatase 2A (PPI2A) as A Potential Drug Target

Target Name: PPP2R2D

NCBI ID: G55844

Serine/threonine-protein Phosphatase 2A (PPI2A) as A Potential Drug Target

PPP2R2D: A Potential Drug Target and Biomarker forserine/threonine-Protein Phosphatase 2A (PPI2A) 55 kDa Regulatory Subunit B Delta Isoform

Introduction

Serine/threonine-protein phosphatase 2A (PPI2A) is a key enzyme in the PI3K/Akt signaling pathway, which is involved in various cellular processes, including cell survival, angiogenesis, and inflammation. PPI2A is a 55 kDa protein that is highly conserved, and various isoforms have been identified in different species. One of the most interesting is the delta isoform (isoform A), which is unique among its isoforms due to a specific missense mutation.

The PPI2A signaling pathway is a complex network that involves multiple protein components, including PPI2A, PPI2B, PPI2C, PPI2D, PPI2E, PPI2F, PPI2G, PPI2H, PPI2I, PPI2J, PPI2K, PPI2L, PPI2M, PPI2N, PPI2O, PPI2P, PPI2Q, PPI2R , PPI2S, PPI2T, PPI2U, PPI2V, PPI2W, PPI2X, PPI2Y, PPI2Z, PPI2AA, PPI2AB, PPI2AC, PPI2AD, PPI2AE, PPI2AF, PPI2AG, PPI2AH, PPI2AI, PPI2AJ, PPI2AK, PPI2AL, PPI2AM, PPI2AN, PPI2AO, PPI2 AP, PPI2AQ , PPI2AR, PPI2AS, PPI2AT, PPI2AU, PPI2AV, PPI2AW, PPI2AX, PPI2AY, PPI2AZ, PPI2B0, PPI2B1, PPI2B2, PPI2B3, PPI2B4, PPI2B5, PPI2B6, PPI2B7, PPI2B8, PPI2B9, PPI2BQ, PPI2BR, PPI2BS , PPI2BX, PPI2BY, PPI2BZ , PPI2C0, PPI2C1, PPI2C2, PPI2C3, PPI2C4, PPI2C5, PPI2C6, PPI2C7, PPI2C8, PPI2C9, PPI2CA, PPI2CB, PPI2CBD, PPI2CCD, PPI2CDI, PPI2CFC, PPI2CFE, PPI2CFL, PPI2CFF, PPI2CG, PPI2 CGH, PPI2CID, PPI2CIG, PPI2CJ, PPI2CK , PPI2CL, PPI2CLL, PPI2CKL, PPI2CLL, PPI2CKL, PPI2CKL, PPI2CKL, PPI2CKL, PPI2CL, PPI2CLL, PPI2CLL, PPI2CLL, PPI2CLL, PPI2CL, PPI2CLL, PPI2CL, PPI2CLL, PPI2CLL, PPI2CLL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL , PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL , PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL , PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL , PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL , PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL , PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL , PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL , PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL , PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL, PPI2CL,

Protein Name: Protein Phosphatase 2 Regulatory Subunit Bdelta

Functions: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity)

More Common Targets