Regulation of Protein Synthesis By PPH Protein (G55291)

Target Name: PPP6R3

NCBI ID: G55291

Regulation of Protein Synthesis By PPH Protein

PPH (phosphoproteasome) is a complex protein that plays a crucial role in regulating protein synthesis in cells. PPHs are composed of a protein fragment (42 amino acids) and a regulatory protein (26 amino acids), which forms a complex with a specific protein substrate (23 amino acids). The protein fragment of PPH is composed of two distinct regions: a N-terminal region (residues 1-18), and a C-terminal region (residues 19-52). The N-terminal region contains a critical domain that is involved in the formation of the PPH-protein-substrate complex, while the C-terminal region contains a hydrophobic region that is involved in the stability of the PPH structure.

The KIAA1558 gene, located on chromosome 16 at position 6.3 kb, encodes a protein known as PPP6R3 (phosphoproteasome regulatory subunit 6A). This gene is a member of the PPH gene family and is responsible for the regulation of protein synthesis in the cell. PPP6R3 is a 198 amino acid protein with a calculated molecular mass of 21.1 kDa. It has a single subunit structure and is expressed in the cytoplasm of the cell.

Function

PPP6R3 is a key regulator of protein synthesis in the cell. It plays a critical role in the formation of the PPH-protein-substrate complex, which is the critical step in the regulation of protein synthesis. The PPH-protein-substrate complex is composed of the PPH protein fragment and the protein substrate, which is a specific protein that is bound to the PPH protein. The PPH protein fragment of PPP6R3 is responsible for the formation of the complex, while the protein substrate is the protein that is bound to the PPH protein fragment.

The PPH-protein-substrate complex is a protein-protein interaction that is critical for the regulation of protein synthesis. The PPH protein fragment of PPP6R3 contains a critical domain that is involved in the formation of the PPH-protein-substrate complex. This domain is known as the N-terminal region and is composed of the amino acids Asp11, Asp12, Asp13, Asp14, Asp15, Asp16, Asp17, Asp18, and Asp19. The N-terminal region of PPP6R3 is responsible for the formation of the protein-protein interaction between PPP6R3 and the protein substrate.

The C-terminal region of PPP6R3 is responsible for the stability of the PPH structure. This region is composed of the amino acids Asn20, Asn21, Asn22, Asn23, Asn24, Asn25, Asn26, Asn27, Asn28, Asn29, Asn30, Asn31, Asn32, Asn33, Asn34, Asn35, Asn36, Asn37, Asn38, Asn39, Asn40, Asn41, Asn42, Asn43, Asn44, Asn45, Asn46, Asn47, Asn48, Asn49, Asn50, Asn51, Asn52, Asn53, Asn54, Asn55, Asn56, Asn57, Asn58, Asn59, Asn60, Asn61, Asn62, Asn63, Asn64, Asn65, Asn66, Asn67, Asn68, Asn69, Asn70, Asn71, Asn72, Asn73, Asn74, Asn75, Asn76, Asn77, Asn78, Asn79, Asn80, Asn81, Asn82, Asn83, Asn84, Asn85, Asn86, Asn87, Asn88, Asn89, Asn90, Asn91, As

Protein Name: Protein Phosphatase 6 Regulatory Subunit 3

Functions: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance

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