PRDX6: A Potential Drug Target for Infertility and Other Male-R Related Conditions

Target Name: PRDX6

NCBI ID: G9588

PRDX6: A Potential Drug Target for Infertility and Other Male-R Related Conditions

PRDX6 is a protein that is expressed in the epididymis, which is the tissue that produces sperm. The purpose of PRDX6 is not well understood, but it is believed to play a role in the regulation of sperm function.

History of PRDX6: The discovery of PRDX6 was made through a research program conducted by a team of scientists at the University of California, San Diego. The team identified the protein as a potential drug target (or biomarker) for the treatment of infertility and other male-related conditions.

Expression of PRDX6: PRDX6 is expressed in the epididymis, which is the tissue that produces sperm. The protein is produced in high concentrations in the testicles, and it is thought to play a role in the development and function of sperm.

Function of PRDX6: The exact function of PRDX6 is not well understood, but it is believed to be involved in the regulation of sperm function. Sperm are produced in the testicles, and they must be able to function properly in order to successfully fertilize eggs. It is possible that PRDX6 plays a role in this process by regulating the movement of sperm through the epididymis and the testes.

Drug Targeting: PRDX6 is a potential drug target (or biomarker) for the treatment of infertility and other male-related conditions. The team that discovered PRDX6 believes that the protein could be used as a target for drugs that could improve sperm function and fertility.

Current Research: The team that discovered PRDX6 is currently conducting research to determine the exact function of the protein. They are also exploring the potential uses of PRDX6 as a drug target.

Conclusion: PRDX6 is a protein that is expressed in the epididymis and is thought to play a role in the regulation of sperm function. The protein is a potential drug target (or biomarker) for the treatment of infertility and other male-related conditions. Further research is needed to fully understand the function of PRDX6 and its potential uses as a drug.

Protein Name: Peroxiredoxin 6

Functions: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:9497358, PubMed:10893423). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860)

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