PPP1R3A: A Glycogen and Sarcoplasmic Reticulum Binding Subunit as a Potential Drug Target and Biomarker

Target Name: PPP1R3A

NCBI ID: G5506

Other Name(s): glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle | glycogen-associated regulatory subunit of protein phosphatase-1 | protein phosphatase 1 regulatory subunit 3A | Protein phosphatase 1 glycogen-associated regulatory subunit | Protein phosphatase type-1 glycogen targeting subunit | serine /threonine specific protein phosphatase | GM | PP1G | PPR3A_HUMAN | PPP1R3 | protein phosphatase 1, regulatory (inhibitor) subunit 3A | Protein phosphatase 1 regulatory subunit 3A | protein phosphatase type-1 glycogen targeting subunit | type-1 protein phosphatase skeletal muscle glycogen targeting subunit | protein phosphatase 1 glycogen- associated regulatory subunit | protein phosphatase 1 regulatory subunit GM | RG1

PPP1R3A: A Glycogen and Sarcoplasmic Reticulum Binding Subunit as a Potential Drug Target and Biomarker

PPPs (phosphatidylinositol 4-phosphate) are a family of enzymes that play a crucial role in various cellular processes, including the regulation of cell signaling, intracellular signaling, and protein synthesis. One of the PPs, PPP1R3A (phosphorotidylinositol 1-phosphate-regulated protein 3A), has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and metabolic disorders.

In this article, we will provide an overview of PPP1R3A, including its function, localization, and potential drug targets. We will also discuss the current research on PPP1R3A as a potential biomarker for various diseases and its potential as a drug target.

Function and Localization of PPP1R3A

PPP1R3A is a protein that belongs to the PPP family and is expressed in various tissues, including muscle, brain, and heart. It is primarily localized to the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR), which are specialized organelles responsible for storing and transporting proteins. PPP1R3A is also known to be located in the cytosol, which is the fluid inside the cell that contains various cellular components and enzymes.

PPP1R3A is a glycogen-binding protein and is involved in the regulation of glycogen metabolism. It is known to interact with the protein Phosphofusin (PFAS) and the protein

Protein Name: Protein Phosphatase 1 Regulatory Subunit 3A

Functions: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity)

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