PPP1R13L: A Potential Drug Target and Biomarker (G10848)

Target Name: PPP1R13L

NCBI ID: G10848

PPP1R13L: A Potential Drug Target and Biomarker

PPP1R13L, also known asBeclin-1, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of the homeostasis of the cells, and its dysfunction has been implicated in various diseases, including neurodegenerative disorders, cardiomyopathies, and renal diseases. Therefore, identifying potential drug targets and biomarkers for PPP1R13L is of great interest.

Drug Targets

PPP1R13L has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. PPP1R13L is a G protein-coupled receptor (GPCR), which means that it can interact with protein-coding molecules called GPCRs. GPCRs are a family of transmembrane proteins that play a crucial role in cellular signaling. They are involved in various signaling pathways, including the regulation of ion channels, neurotransmitter release, and cell survival. Therefore, blocking PPP1R13L could potentially lead to therapeutic effects in diseases that are caused by the dysfunction of these signaling pathways.

Biomarkers

PPP1R13L has also been identified as a potential biomarker for various diseases. Its expression has been observed in various disease-related tissues, including neurodegenerative disorders, cardiomyopathies, and renal diseases. Therefore, measuring the expression level of PPP1R13L could be a diagnostic tool for these diseases. Additionally, its function as a drug target could be evaluated by using techniques such as knockdown or overexpression experiments to determine its effects on cellular signaling pathways.

Expression and Function

PPP1R13L is a highly expressed gene in various tissues of the body, including the brain, heart, and kidneys. It is expressed in the brain and is involved in the regulation of neurotransmitter release and the maintenance of the blood-brain barrier. It is also expressed in the heart and is involved in the regulation of ion channels and neurotransmitter release. Additionally, it is expressed in the kidneys and is involved in the regulation of water and electrolyte balance.

PPP1R13L is a GPCR that is involved in the regulation of various cellular processes, including neurotransmitter release, ion channels, and cell survival. Its function as a drug target is suggested by its unique structure and its involvement in various diseases. Therefore, the study of PPP1R13L is of great interest in the development of new therapeutic approaches for various diseases.

Protein Name: Protein Phosphatase 1 Regulatory Subunit 13 Like

Functions: Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540)

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