PPP1R2P2: A Drug Target / Disease Biomarker (G54036)

Target Name: PPP1R2P2

NCBI ID: G54036

Other Name(s): protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 2 | Protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 2

PPP1R2P2: A Drug Target / Disease Biomarker

PPP1R2P2, also known as PPP1R2, is a protein that is expressed in various tissues throughout the body. It is a key regulator of the poly(ADP-ribose) polymerase (PARP) pathway, a protein that helps maintain cellular energy homeostasis. PARP is involved in the repair of DNA damage, and is often targeted by drugs as a potential drug target or biomarker.

The PARP pathway is a complex series of proteins that work together to ensure that damaged DNA is repaired and segregated into the cell's nucleus. PPP1R2P2 is the final step in this pathway, and is involved in the regulation of the activity of PARP.

In cellular energy homeostasis, PARP plays a crucial role in the regulation of ATP (adenosine triphosphate) levels. ATP is the primary energy source for all cellular processes, and is essential for the maintenance of cellular order and homeostasis. The PARP pathway helps to maintain the proper levels of ATP in the cell by regulating the activity of the PARP enzyme.

PPP1R2P2 is a key regulator of the PARP pathway, and is involved in the regulation of the activity of PARP. It does this by interacting with the protein PARP1 and the nucleotide GDP. This interaction between PPP1R2P2 and PARP1 allows PPP1R2P2 to regulate the activity of PARP and control the levels of ATP in the cell.

The PARP pathway is a well-established target for drugs, and PPP1R2P2 is no exception. Many drugs that are currently in use are designed to inhibit the activity of PARP1, with the goal of blocking the repair of DNA damage. These drugs are effective in treating certain types of cancer, but can also have unintended consequences, such as increasing the risk of bleeding or other adverse effects.

In addition to its role in the treatment of cancer, PPP1R2P2 is also a potential biomarker for certain types of cancer. The PARP pathway is often dysregulated in cancer cells, and changes in the activity of PARP1 can be an indicator of the presence of cancer. Therefore, measuring the activity of PARP1 can be a useful diagnostic tool for certain types of cancer.

In conclusion, PPP1R2P2 is a protein that is involved in the regulation of the PARP pathway. It plays a crucial role in the maintenance of cellular energy homeostasis and is a potential drug target or biomarker for certain types of cancer. Further research is needed to fully understand the role of PPP1R2P2 in cellular biology and its potential as a therapeutic target.

Protein Name: Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 Pseudogene 2

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