PPP1R36: A Potential Drug Target and Biomarker for Protein Phosphatase 1 Regulatory Subunit 36

Target Name: PPP1R36

NCBI ID: G145376

Other Name(s): Protein phosphatase 1 regulatory subunit 36 | C14orf50 | PPR36_HUMAN | protein phosphatase 1 regulatory subunit 36

PPP1R36: A Potential Drug Target and Biomarker for Protein Phosphatase 1 Regulatory Subunit 36

Introduction

Protein phosphorylation is an important biochemical process that plays a key role in biological processes such as cell signal transduction, metabolic regulation, cell adhesion, cell migration, and apoptosis. In cells, phosphorylase is an enzyme that catalyzes the phosphorylation reaction, among which protein phosphorylase 1 (PPI) is one of the most important enzymes. PPI is a protein composed of multiple subunits, including regulatory subunit 36 鈥嬧??(PPI-R36) of PPI.

PPI-R36 is a conserved protein that plays an important role in a variety of biological processes. During the process of apoptosis, PPI-R36 is involved in regulating the process of apoptosis. During the cell adhesion process, PPI-R36 participates in the interaction between cells and matrix, thereby promoting cell adhesion. During the cell signal transduction process, PPI-R36 participates in the phosphorylation reaction, thereby regulating the signal transduction pathway.

In recent years, with the continuous development of science and technology, people's research on PPI-R36 has gradually deepened. Many studies have shown that PPI-R36 plays an important role in a variety of diseases, such as cancer, neurodegenerative diseases, inflammation, etc. At the same time, many studies have also shown that PPI-R36 has good clinical prospects as a drug target.

This article will introduce the structure, function, mechanism of action and possibility of PPI-R36 as a drug target, and explore the application prospects of PPI-R36 in biomedical research.

structure

PPI is composed of multiple subunits, including regulatory subunit 36 鈥嬧??(PPI-R36) of PPI and catalytic subunit 1 (PPI-C1) of PPI. PPI-R36 is an important component in PPI and is part of the active center of PPI. PPI-R36 has a central conserved 伪-helical structure, which includes a free 伪-helical region, a 尾-sheet and a free 尾-roll.

PPI-R36 functions

PPI-R36 plays an important role in a variety of biological processes. During the process of apoptosis, PPI-R36 is involved in regulating the process of apoptosis. PPI-R36 can bind to the apoptosis signaling molecule Bcl-2, thereby inhibiting the phosphorylation of Bcl-2, thereby inhibiting cell apoptosis. During the cell adhesion process, PPI-R36 participates in the interaction between cells and matrix, thereby promoting cell adhesion. PPI-R36 can bind to extracellular matrix proteins, thereby enhancing the interaction between extracellular matrix proteins and cell membranes and promoting cell adhesion.

Mechanism of action of PPI-R36

The mechanism of action of PPI-R36 is through phosphorylation reaction. PPI is a phosphorylase that transfers phosphate groups to other proteins. PPI-R36 is an important component in PPI and is part of the active center of PPI. PPI-R36 has a central conserved 伪-helical structure, which includes a free 伪-helical region, a 尾-sheet and a free 尾-roll. In the phosphorylation reaction, the 伪-helical structure of PPI-R36 can accommodate multiple phosphate groups to achieve the phosphorylation reaction.

as a drug target

In recent years, with the continuous development of science and technology, people have gradually deepened their research on PPI-R36 as a drug target. Many studies have shown that PPI-R36 plays an important role in a variety of diseases, such as cancer, neurodegenerative diseases, inflammation, etc. At the same time, many studies have also shown that PPI-R36 has good clinical prospects as a drug target.

PPI-R36 as a drug target needs to have high specificity.

Protein Name: Protein Phosphatase 1 Regulatory Subunit 36

Functions: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes

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