PI14B: A Potential Drug Target and Biomarker for Many Diseases

Target Name: PPP1R14B

NCBI ID: G26472

PI14B: A Potential Drug Target and Biomarker for Many Diseases

PPP1R14B (SOM172) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its primary function is to regulate the activity of the protein PIK3CA, which is known to play a role in the development and progression of many diseases, including cancer.

PPI14B is a key regulator of the activity of PIK3CA, and is often targeted by drugs that are used to treat these diseases. For example, the drug sorafenib is a targeted treatment for EGFR-positive locally advanced or locally advanced disease. As a drug for metastatic lung cancer, its mechanism of action is to inhibit the growth of EGFR-positive lung cancer cells by inhibiting signal transduction mediated by EGFR tyrosine kinase.

PPI14B is also a potential biomarker for many diseases, including cancer. Its expression has been observed in a variety of cancer types, including breast, ovarian, and colorectal cancers. Additionally, it has also been shown to be elevated in the blood of patients with certain types of cancer, which could make it a useful diagnostic tool in some cases.

In addition to its potential as a drug target and biomarker, PPI14B is also of interest to researchers because of its unique structure. PPI14B is a protein that consists of 14 conserved amino acids and its length is 193 amino acids. Its structural features are highly conserved helices and 尾-sheet structures, which make it an attractive molecular target.

Furthermore, PPI14B also has been shown to play a role in many different cellular processes in the body. For example, it has been shown to be involved in the regulation of cell adhesion, cell migration, and the signaling of various signaling pathways. These functions are important for the proper functioning of many different tissues and organs in the body, and may be potential targets for drugs that are used to treat a wide range of diseases.

Overall, PPI14B is a protein that is of great interest to researchers because of its unique structure and its role in many different cellular processes in the body. Its potential as a drug target and biomarker make it an attractive target for the development of new therapies for a wide range of diseases.

Protein Name: Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B

Functions: Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity)

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