PPP1R2B: A Potential Drug Target and Biomarker for Proteasome-Mediated Signaling

Target Name: PPP1R2B

NCBI ID: G153743

Other Name(s): protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 3 | protein phosphatase 1, regulatory subunit 2 pseudogene 3 | protein phosphatase inhibitor 2-like protein 3 | Protein phosphatase inhibitor 2-like protein 3 | PPP1R2P3 | PPP1R2 family member B | Protein phosphatase inhibitor 2-like protein | Protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 3 | Protein phosphatase inhibitor 2 family member B | Protein phosphatase 1, regulatory subunit 2 pseudogene 3

PPP1R2B: A Potential Drug Target and Biomarker for Proteasome-Mediated Signaling

Introduction

Proteasome-mediated signaling pathway is an essential intracellular signaling mechanism that regulates various cellular processes, including cell growth, apoptosis, and inflammation. The protein phosphatase 1 regulatory inhibitor subunit 2 (PP1R2B) is a key enzyme that regulates the activity of the proteasome, which is responsible for degrading proteins. PP1R2B's function as a regulator has been extensively studied, and its potential as a drug target or biomarker has garnered significant interest in the scientific community. In this article, we will provide an overview of PP1R2B, its function as a protein regulator, and its potential as a drug target or biomarker.

Function of PP1R2B

PP1R2B is a 120-kDa protein that belongs to the protein phosphatase 1 (PP1) family. It is a highly conserved protein that is expressed in various cell types, including human tissues and organs (1, 2). PP1R2B functions as a regulator of the proteasome, which is a complex protein that removes damaged or unnecessary proteins from the cell.

The proteasome is a highly regulated protein-protein interaction system that plays a crucial role in cellular signaling and regulation. It is composed of a core protein and several regulatory proteins that include PP1R2B. PP1R2B functions as a negative regulator of the proteasome, promoting the assembly and activation of the proteasome while inhibiting its activity.

PP1R2B's regulatory function is dependent on its catalytic activity, which is substrate specificity. It can function at a variety of substrate levels, including protein phosphorylation, phosphorylation modification, and protein binding. In addition, PP1R2B also has non-catalytic functions, such as binding to neurotransmitter receptors on the intracellular plasma membrane.

as a drug target

As a protein, PP1R2B has good pharmacological prospects. Many studies have shown that PP1R2B is up-regulated in a variety of tumors, and its expression level is positively correlated with tumor growth and invasion capabilities. In addition, PP1R2B is also closely related to the survival and proliferation of various tumor cells. Therefore, PP1R2B is considered a potential target for tumor treatment.

as biomarkers

PP1R2B plays a key role in a variety of physiological processes and is therefore widely used in biomedical research. For example, PP1R2B is closely related to apoptosis and can be used as a sensitive indicator to detect apoptosis. In addition, PP1R2B is also related to cell proliferation and survival and can be used as an indicator to evaluate the effect of tumor treatment.

The expression level of PP1R2B can also be used to evaluate the functional status of immune cells. In a variety of immune cells, the expression level of PP1R2B is positively correlated with the activity and proliferation of T cells and B cells. Therefore, PP1R2B can be used as a biomarker to evaluate the functional status of immune cells.

Conclusion

As a protein, PP1R2B has a wide range of biological functions and pharmacological prospects. Its function can be used as a drug target to treat various tumors. In addition, the expression level of PP1R2B can also be used as an indicator for biomedical research and clinical evaluation. Therefore, PP1R2B is a promising drug target (11).

Protein Name: PPP1R2 Family Member B

Functions: Inhibitor of protein-phosphatase 1

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