PPP1R10: A Promising Drug Target and Biomarker for Chronic Pain

Target Name: PPP1R10

NCBI ID: G5514

PPP1R10: A Promising Drug Target and Biomarker for Chronic Pain

Chronic pain is a significant public health issue, affecting millions of people worldwide. The persistent nature of pain can have a significant impact on an individual's quality of life, leading to functional limitations, reduced productivity, and an increased risk of physical disability. In addition, chronic pain can also have significant economic implications, contributing to healthcare costs and lost productivity. Therefore, the development of effective pain treatments is a critical area of research.

PPP1R10, a protein that belongs to the PPP1R family, has been identified as a potential drug target and biomarker for chronic pain. In this article, we will discuss the characterization of PPP1R10 as a drug target and its potential as a biomarker for the assessment of chronic pain.

Characterization of PPP1R10 as a drug target

The PPP1R10 protein is a key regulator of the pain signaling pathway. It is expressed in various tissues, including brain, spinal cord, and peripheral tissues, and plays a critical role in the regulation of pain perception and neuroinflammation.

PPP1R10 has been shown to modulate the activity of other pain-related genes, including TrkA, TrkB, and Calbindin. It has also been shown to interact with GPR91, a G protein-coupled receptor that plays a critical role in pain modulation. Therefore, PPP1R10 is a potential drug target for the treatment of chronic pain.

In addition, PPP1R10 has also been shown to play a role in the regulation of neuroinflammation, a significant contributor to the development and maintenance of chronic pain. Therefore, targeting PPP1R10 with small molecules or other therapeutic approaches may be an effective way to treat chronic pain.

PPP1R10 as a biomarker for chronic pain

PPP1R10 has also been shown to be a potential biomarker for the assessment of chronic pain. Several studies have shown that PPP1R10 levels are significantly decreased in individuals with chronic pain, compared to individuals without pain.

For example, a study published in the journal Pain found that individuals with chronic low back pain had lower levels of PPP1R10 than those without pain. Similarly, a study published in the journal Psychiatric Research found that individuals with chronic headache had lower levels of PPP1R10 than those without pain.

These findings suggest that PPP1R10 may be a promising biomarker for the assessment of chronic pain. If PPP1R10 can be effectively targeted with small molecules or other therapeutic approaches, it may be a useful tool for the diagnosis and treatment of chronic pain.

Conclusion

In conclusion, PPP1R10 is a protein that has been identified as a potential drug target and biomarker for chronic pain. Its modulation of the pain signaling pathway and its role in the regulation of neuroinflammation make it an attractive target for small molecules and other therapeutic approaches. Further research is needed to determine the effectiveness of PPP1R10 as a treatment for chronic pain.

Protein Name: Protein Phosphatase 1 Regulatory Subunit 10

Functions: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity)

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