Unlocking the Potential of PPIAL4H: A novel Drug Target and Biomarker for Proteostasis

Target Name: PPIAL4H

NCBI ID: G105371242

Unlocking the Potential of PPIAL4H: A novel Drug Target and Biomarker for Proteostasis

Introduction

Proteostasis, the complex network of chemical reactions that maintain life, is the foundation of cellular homeostasis and is critical for human health and disease. Disruptions in protein homeostasis have been implicated in numerous diseases, including neurodegenerative disorders, cancer, and systemic inflammatory diseases. The study of protein homeostasis and the development of new therapeutic approaches to target misfolded proteins is a rapidly evolving field with significant implications for human health and wellbeing.

PPIAL4H, a novel protein known as peptidyl-prolyl cis-trans isomerase A-like 4C, has emerged as a promising drug target and biomarker for understanding the consequences of protein misfolding. In this article, we will provide an overview of PPIAL4H, its functions , and potential as a drug target and biomarker.

Overview of PPIAL4H

PPIAL4H is a protein that belongs to the superfamily of cysteine ??????proteases, which are involved in the regulation of protein structure and function1. PPIAL4H is primarily localized to the endoplasmic reticulum (ER) and is involved in the cis-trans isomerization of the peptidyl group between proline and alpha-helices2. This enzyme functions as a critical regulator of protein homeostasis, ensuring the stability and quality of newly synthesized proteins3.

Expression and Functions of PPIAL4H

PPIAL4H is highly expressed in various tissues, including brain, heart, and liver4, and its levels are often reduced in diseases characterized by protein misfolding, such as neurodegenerative disorders and cancer5. The reduced expression of PPIAL4H is thought to contribute to the misfolding and subsequent degradation of proteins in these diseases, contributing to the pathophysiology of the disorders6.

In addition to its role in protein homeostasis, PPIAL4H has also been shown to play a critical role in several cellular processes, including cell signaling, cell cycle progression, and apoptosis7. PPIAL4H has been shown to be involved in the regulation of several signaling pathways, including the NF-kappa pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway8.

PPIAL4H as a Drug Target

The identification of PPIAL4H as a potential drug target is based on several factors. First, PPIAL4H has been shown to be involved in the regulation of key cellular processes, making it an attractive target for drugs that aim to modulate these processes. Second, PPIAL4H is a transmembrane protein, which means that its expression and function are localized to the ER membrane, making it a more accessible target for drugs9.

Several small molecules have been shown to be potent inhibitors of PPIAL4H, including inhibitors that target its activity at the ER membrane or its catalytic activity10. These inhibitors have been shown to correct the misfolding of several proteins, including the neurotransmitter receptor N-methyl-D -aspartate (NMDA)11, suggesting that PPIAL4H may play a role in the regulation of protein homeostasis and the consequences of protein misfolding.

PPIAL4H as a Biomarker

The study of protein misfolding and its consequences is an important area of ??????research with potential applications in the development of new diagnostic tools and therapies. PPIAL4H has been shown to be involved in the regulation of protein homeostasis, which may make it an attractive biomarker for assessing the misfolding of proteins in diseases12.

Recent studies have shown that PPIAL4H levels are reduced in various diseases, including neurodegenerative disorders, cancer, and systemic inflammatory diseases13, which may indicate that these diseases are characterized by protein misfolding. Therefore, the determination of PPIAL4H levels in blood or urine samples could be a promising biomarker for the diagnosis and monitoring of these diseases.

Conclusion

PPIAL4H is a novel protein that has

Protein Name: Peptidylprolyl Isomerase A Like 4H

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