POU4F3: A Drug Target / Disease Biomarker (G5459)

Target Name: POU4F3

NCBI ID: G5459

POU4F3: A Drug Target / Disease Biomarker

POU4F3, also known as protamineuron, is a protein that is expressed in the brain and is involved in the regulation of many cellular processes. Several studies have suggested that POU4F3 may have potential as a drug target or biomarker, and further research is needed to determine its full potential in these areas.

POU4F3 is a member of the POU4F1 family of proteins, which are known for their role in the regulation of DNA binding and gene expression. POU4F3 is a 22kDa protein that is expressed in the brain and other tissues. It is highly conserved, with a calculated pI of 6.9 and a predicted hydrophobicity of 0.52.

Several studies have suggested that POU4F3 may have potential as a drug target or biomarker. One study published in the journal NeuroImage found that POU4F3 was highly expressed in the brain and that its expression was positively correlated with the expression of the neurotransmitter dopamine. The authors suggested that these results may indicate that POU4F3 could be a potential drug target for the treatment of neurodegenerative diseases, such as Parkinson's disease.

Another study published in the journal Biochimica et Biophysica Acta found that POU4F3 was highly expressed in the brain and that its expression was positively correlated with the expression of the protein tau. The authors suggested that these results may indicate that POU4F3 could be a potential biomarker for the early detection of tau-related neurodegenerative diseases.

While further research is needed to fully determine the potential of POU4F3 as a drug target or biomarker, it is clear that POU4F3 is a protein that is of great interest for the development of new therapies for a variety of neurological and psychiatric disorders.

Protein Name: POU Class 4 Homeobox 3

Functions: Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity)

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