HERC6: A Protein Ligase for Cellular Trafficking and Maintenance

Target Name: HERC6

NCBI ID: G55008

Other Name(s): Probable E3 ubiquitin-protein ligase HERC6 (isoform 2) | hect domain and RLD 6 | HERC6 variant 1 | Hect domain and RLD 6 | potential ubiquitin ligase | HECT-type E3 ubiquitin transferase HERC6 | FLJ20637 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | HECT domain and RCC1-like domain-containing protein 6 | HERC6 variant 2 | Probable E3 ubiquitin-protein ligase HERC6 | Potential ubiquitin ligase | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6, transcript variant 1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6, transcript variant 2 | Probable E3 ubiquitin-protein ligase HERC6 (isoform 1) | HERC6_HUMAN

HERC6: A Protein Ligase for Cellular Trafficking and Maintenance

Ubiquitin-protein ligases are a family of enzymes that play a crucial role in the regulation of protein homeostasis, including the removal of misfolded or damaged proteins. One of the most well-known ubiquitin-protein ligases is HERC6 (also known as Probable E3 ubiquitin-protein ligase), which is a protein that localizes to the endoplasmic reticulum (ER) and removes damaged or misfolded proteins to prevent their release into the cytosol. HERC6 is a key enzyme in the ubiquitin-protein ligase family and is involved in cellular trafficking, maintenance, and repair.

HERC6 is a 21-kDa protein that is expressed in most tissues and cells. It is a member of the ubiquitin-protein ligase family 6 (UPL6), which includes enzymes that remove damaged or misfolded proteins from the endoplasmic reticulum, such as the ubiquitin-protein ligase 1 (UPL1) and the ubiquitin-protein ligase 2 (UPL2). HERC6 is characterized by its unique N-terminal region, which contains a conserved catalytic core and a N-terminal hypervariable region (HVR) that is involved in its specificity for its target protein.

HERC6's catalytic core is composed of a nucleotide-binding oligomerization domain (NBD) and a catalytic domain that includes a parallel beta-sheet and a distinct alpha-helices. The NBD is responsible for binding the target protein, while the catalytic domain is responsible for the ligation of the ubiquitin bond between the protein and the ubiquitin-protein ligase. The N-terminal HVR is involved in the recognition of specific protein targets and is thought to play a role in the stability and specificity of the HERC6 enzyme.

HERC6 has been shown to be involved in the regulation of a wide range of cellular processes, including cell signaling, cell division, and DNA replication. It is a key regulator of the ubiquitin system, which is involved in the degradation of damaged or misfolded proteins and is essential for maintaining cellular homeostasis. HERC6 is also involved in the regulation of cell adhesion, migration, and the formation of tissues and organs.

In addition to its role in cellular signaling and homeostasis, HERC6 is also a potential drug target. The hypervariable region of HERC6 has been shown to be involved in the regulation of protein stability and could be a target for small molecules that can modulate the stability of target proteins. Additionally, HERC6 is known to be involved in the regulation of DNA replication, which is a critical process for cell growth and division. Therefore, inhibitors of HERC6 could be useful in treating cancer and other diseases that are characterized by the uncontrolled growth and division of cells.

In conclusion, HERC6 is a protein ligase that is involved in the regulation of cellular trafficking, maintenance, and repair. It is a key enzyme in the ubiquitin-protein ligase family and is involved in the degradation of damaged or misfolded proteins, as well as the regulation of cell adhesion, migration, and DNA replication. HERC6 is a potential drug target and could be useful in treating a wide range of diseases. Further research is needed to fully understand the role of HERC6 in cellular biology and to develop effective inhibitors of this enzyme.

Protein Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 6

Functions: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates

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