HINT1: A Potential Drug Target and Biomarker (G3094)

Target Name: HINT1

NCBI ID: G3094

HINT1: A Potential Drug Target and Biomarker

HINT1, also known as Hint-1, is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a key regulator of cell growth and differentiation, and has been implicated in a number of diseases, including cancer, neurodegenerative disorders, and gastrointestinal diseases.

One of the key features of HINT1 is its role in cell signaling. It is a negative regulator of the TGF-β pathway, which is a well-known regulator of cell growth and differentiation. This means that when TGF-β signaling is activated, HINT1 works to inhibit it.

This role in cell signaling makes HINT1 an attractive drug target. By inhibiting TGF-β signaling, HINT1 has been shown to have a number of potential therapeutic effects. For example, it has been shown to be a potential treatment for a variety of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

In addition to its potential therapeutic uses, HINT1 is also a valuable biomarker for a number of diseases. For example, it has been shown to be a potential biomarker for a variety of cancer types, including breast, ovarian, and prostate cancer. This makes it an important tool for the development of new cancer therapies.

One of the challenges in studying HINT1 is its complex biology. While it is known that HINT1 plays a key role in cell signaling, it is not yet clear exactly how it works at the molecular level. This is an area that is in need of further research, as understanding the underlying mechanisms of HINT1's role in cell signaling is key to its potential as a drug target.

In conclusion, HINT1 is a protein that has the potential to be a drug target and biomarker for a variety of diseases. Its role in cell signaling makes it an attractive target for the development of new therapies, while its potential as a biomarker makes it an important tool for the diagnosis and treatment of a wide range of diseases. Further research is needed to fully understand the mechanisms of HINT1's role in cell signaling and its potential as a drug and biomarker.

Protein Name: Histidine Triad Nucleotide Binding Protein 1

Functions: Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:15703176, PubMed:16835243, PubMed:17337452, PubMed:17217311, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367, PubMed:22329685). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (PubMed:15703176, PubMed:16835243). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (PubMed:15703176, PubMed:22329685, PubMed:17337452). Hydrolyzes 3-indolepropionic acyl-adenylate, tryptamine adenosine phosphoramidate monoester and other fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17337452, PubMed:23614568, PubMed:29787766, PubMed:17217311, PubMed:28691797, PubMed:31990367). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (PubMed:30772266). In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (PubMed:16014379, PubMed:22647378). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis (PubMed:16835243). Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:19112177). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RGS17 (PubMed:31088288). Deconjugates SUMO1 from RANGAP1 (By similarity)

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