HMBOX1: A Protein Implicated in Cellular and Immune Processes

Target Name: HMBOX1

NCBI ID: G79618

HMBOX1: A Protein Implicated in Cellular and Immune Processes

HMBOX1 (HOT1) is a heat shock factor (HIF) gene that is expressed in a variety of organisms, including humans. It is a key regulator of the response to thermal stress, such as fever, and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

HMBOX1 is a protein that is composed of 25 amino acid residues and has a calculated molecular weight of 30.5 kDa. It is expressed in a variety of tissues and cells, including the brain, heart, liver, and muscle. It is highly heat-resistant and can withstand temperatures up to 100掳C.

HMBOX1 has been shown to play a role in the regulation of cellular processes that are important for the survival and growth of cells. For example, it has been shown to be involved in the regulation of cell cycle progression, apoptosis (programmed cell death), and inflammation.

In addition to its role in cellular processes, HMBOX1 has also been shown to be involved in the regulation of the immune system. For example, it has been shown to be involved in the regulation of T cell development and function, and to play a role in the development of autoimmune diseases.

HMBOX1 has also been shown to be involved in the regulation of inflammation. For example, it has been shown to be involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-alpha (transforming growth factor alpha), and to play a role in the regulation of the migration of immune cells.

In conclusion, HMBOX1 is a protein that has been shown to play a role in a variety of cellular processes that are important for the survival and growth of cells. Its potential as a drug target or biomarker makes it an attractive target for research into a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of HMBOX1 in these diseases and to develop effective treatments.

Protein Name: Homeobox Containing 1

Functions: Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958)

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