HMGB3p19: A Potential Drug Target and Biomarker (G729635)

Target Name: HMGB3P19

NCBI ID: G729635

Other Name(s): High mobility group box 3 pseudogene 19 | high mobility group box 3 pseudogene 19

HMGB3p19: A Potential Drug Target and Biomarker

High mobility group box (HMGB) proteins are a family of non-coding RNAs that play a crucial role in various cellular processes, including DNA replication, repair, and transcription.hmgb3p19 (High mobility group box 3 pseudogene 19) is one of the member of the HMGB family that is widely expressed in various tissues and cells.hmgb3p19 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

HMGB3p19 function

HMGB3p19 is a 21-kDa protein that contains 19 open reading frames (ORFs) including an ORF of 19 exons. The ORFs are dispersed across the protein molecule and are mainly involved in the regulation of DNA replication, repair, and transcription.

HMGB3p19 plays a vital role in the regulation of DNA replication, as it is involved in the recruitment of the DNA replication machinery to the site of the replication break. It helps in the formation of the replication complex, which is the essential unit of DNA replication , and ensures the proper execution of the DNA replication process.

HMGB3p19 is also involved in the regulation of DNA repair. When DNA double strands are damaged, HMGB3p19 helps in the formation of the repair complex, which includes various proteins that aim to repair the damaged site.

HMGB3p19 also plays a significant role in the regulation of transcription. It is involved in the recruitment of RNA polymerase II (RNA-P2) to the nuclear kernel, where it interacts with the RNA-P2 and helps in the initiation of transcription.

HMGB3p19 dysfunction

HMGB3p19 dysfunction has been observed in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In cancer, HMGB3p19 has been shown to be involved in the regulation of cell cycle progression, apoptosis, and angiogenesis. It has been shown to play a role in the development and progression of various types of cancer, including breast, ovarian, and colorectal cancer..

In neurodegenerative diseases, HMGB3p19 has been linked to the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Studies have shown that HMGB3p19 is involved in the regulation of neuroprotective enzymes, such as superoxide dismutase (SOD), which helps in the detoxification of oxidative stress in the brain.

In autoimmune disorders, HMGB3p19 has been implicated in the development and progression of various autoimmune disorders, including rheumatoid arthritis (RA), lupus, and multiple sclerosis (MS).

Drug targeting and biomarker potential

HMGB3p19 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

For the treatment of cancer, HMGB3p19 has been shown to be involved in the regulation of cell cycle progression, apoptosis, and angiogenesis. Therefore, targeting HMGB3p19 with drugs that can inhibit its function may be an effective strategy for the treatment of cancer.

HMGB3p19 has also been shown to be involved in the regulation of neuroprotective enzymes, such as SOD. Therefore, drugs that can enhance the activity of SOD may be an effective strategy for the treatment of neurodegenerative diseases.

HMGB3p19 has also been linked to the development and progression of various autoimmune disorders. Therefore, drugs that can inhibit its function may be an effective strategy for the treatment of autoimmune disorders.

Conclusion

HMGB3p19 is a non-coding RNA that plays a crucial role in various cellular processes, including DNA replication, repair, and transcription. It has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders . Further studies are needed to understand the full function

Protein Name: High Mobility Group Box 3 Pseudogene 19

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