Target Name: HNF4A
NCBI ID: G3172
Other Name(s): HNF-4 | nuclear receptor subfamily 2 group A member 1 | Hepatocyte nuclear factor 4 alpha, transcript variant 6 | Transcription factor 14 | transcription factor HNF-4 | HNF4a7 | HNF4A variant 3 | Hepatocyte nuclear factor 4 alpha, transcript variant 7 | Hepatocyte nuclear factor 4-alpha (isoform 6) | HNF4A variant 5 | HNF4alpha | Hepatocyte nuclear factor 4-alpha (isoform 3) | Hepatic nuclear factor 4 alpha | hepatocyte nuclear factor 4-alpha | Hepatocyte nuclear factor 4-alpha (isoform 9) | MODY1 | HNF4a9 | hepatic nuclear factor 4 alpha | HNF4 | Hepatocyte nuclear factor 4, alpha | Transcription factor-14 | HNF4A_HUMAN | HNF4alpha10/11/12 | FLJ39654 | MODY | Transcription factor HNF-4 | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) | Hepatocyte nuclear factor 4, alpha, transcript variant 1 | Hepatocyte nuclear factor 4-alpha | FRTS4 | Hepatocyte nuclear factor 4-alpha (isoform 5) | HNF-4-alpha | HNF4A variant 1 | HNF4A variant 4 | HNF4a8 | Hepatocyte nuclear factor 4 alpha, transcript variant 2 | HNF4A variant 6 | TCF | HNF4A variant 9 | Hepatocyte nuclear factor 4 alpha, transcript variant 9 | Hepatocyte nuclear factor 4 alpha, transcript variant 3 | TCF14 | Hepatocyte nuclear factor 4 alpha, transcript variant 4 | HNF4A variant 2 | transcription factor 14 | hepatocyte nuclear factor 4 alpha | HNF4A variant 7 | Hepatocyte nuclear factor 4-alpha (isoform 2) | NR2A1 | TCF-14 | Hepatocyte nuclear factor 4 alpha, transcript variant 5 | HNF4A wild type | NR2A21 | Hepatocyte nuclear factor 4-alpha (isoform 1) | Hepatocyte nuclear factor 4-alpha (isoform 4) | Nuclear receptor subfamily 2 group A member 1 | Hepatocyte nuclear factor 4-alpha (isoform 7)

HNF4A: Key Regulator of Gene Expression and Potential Drug Target

HNF4A, also known as HNF4A gene, is a gene that encodes a protein known as the homeobox gene family 4A (HNF4A). The HNF4A gene is a member of the family of transcription factors, which are a group of proteins that regulate gene expression. HNF4A is a key regulator of gene expression in many organisms, including humans.

The HNF4A gene is located on chromosome 11p36 and has been implicated in a number of important biological processes. One of the most well-studied functions of HNF4A is its role in the development and progression of many diseases, including cancer. HNF4A has also been shown to play a key role in the regulation of stem cell proliferation and the development of tissues such as skin, hair and nails.

In addition to its role in disease, HNF4A has also been shown to be a potential drug target. Researchers have identified several potential drug targets for HNF4A, including those that interact with the protein in different ways. One of the most promising potential drug targets for HNF4A is the use of small molecules, such as those derived from natural products, to inhibit the activity of HNF4A and its downstream targets.

Another potential drug target for HNF4A is the use of inhibitors of the HNF4A- transcription factor complex, which includes the protein itself as well as several other proteins that are regulated by HNF4A. These inhibitors have been shown to be effective in cell culture and animal models of disease, and may be a useful tool for the treatment of certain diseases.

In conclusion, HNF4A is a gene that has been shown to play a key role in the development and progression of many diseases, including cancer. It is also a potential drug target, with several potential inhibitors that have been shown to be effective in cell culture and animal models of disease. Further research is needed to fully understand the role of HNF4A in disease and to develop effective treatments for those diseases.

Protein Name: Hepatocyte Nuclear Factor 4 Alpha

Functions: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698)

More Common Targets

HNF4G | HNF4GP1 | HNMT | HNRNPA0 | HNRNPA1 | HNRNPA1L2 | HNRNPA1L3 | HNRNPA1P10 | HNRNPA1P12 | HNRNPA1P16 | HNRNPA1P2 | HNRNPA1P21 | HNRNPA1P27 | HNRNPA1P33 | HNRNPA1P35 | HNRNPA1P36 | HNRNPA1P39 | HNRNPA1P41 | HNRNPA1P5 | HNRNPA1P51 | HNRNPA1P6 | HNRNPA1P60 | HNRNPA1P7 | HNRNPA1P70 | HNRNPA2B1 | HNRNPA3 | HNRNPA3P1 | HNRNPA3P6 | HNRNPAB | HNRNPC | HNRNPCL1 | HNRNPCL2 | HNRNPCL3 | HNRNPCP1 | HNRNPD | HNRNPDL | HNRNPF | HNRNPH1 | HNRNPH2 | HNRNPH3 | HNRNPK | HNRNPKP1 | HNRNPKP2 | HNRNPKP3 | HNRNPKP4 | HNRNPL | HNRNPLL | HNRNPM | HNRNPR | HNRNPU | HNRNPU antisense RNA 1 | HNRNPUL1 | HNRNPUL2 | HNRNPUL2-BSCL2 | HOATZ | HOGA1 | Homeodomain-interacting protein kinase | HOMER1 | HOMER2 | HOMER2P1 | HOMER3 | HOMEZ | HOOK1 | HOOK2 | HOOK3 | Hop2-Mnd1 complex | HOPX | HORMAD1 | HORMAD2 | HORMAD2-AS1 | HOTAIR | HOTAIRM1 | HOTTIP | HOXA-AS2 | HOXA-AS3 | HOXA1 | HOXA10 | HOXA10-AS | HOXA10-HOXA9 | HOXA11 | HOXA11-AS | HOXA13 | HOXA2 | HOXA3 | HOXA4 | HOXA5 | HOXA6 | HOXA7 | HOXA9 | HOXB-AS1 | HOXB-AS3 | HOXB1 | HOXB13 | HOXB2 | HOXB3 | HOXB4 | HOXB5 | HOXB6 | HOXB7 | HOXB8