HNRNPA1P12: A Heterogeneous Nuclear Ribonucleoprotein (HNRNPA1P12) as a Drug Target or Biomarker

Target Name: HNRNPA1P12

NCBI ID: G644037

Other Name(s): heterogeneous nuclear ribonucleoprotein A1 pseudogene 12 | Heterogeneous nuclear ribonucleoprotein A1 pseudogene 12

HNRNPA1P12: A Heterogeneous Nuclear Ribonucleoprotein (HNRNPA1P12) as a Drug Target or Biomarker

Introduction

Heterogeneous nuclear ribonucleoprotein (HNRNPA1P12) is a protein that plays an essential role in various cellular processes. It is a key component of the nucleosome complex, which is responsible for organizing the nuclear chromosomes during the cell cycle. HNRNPA1P12 has been identified as a potential drug target or biomarker due to its unique structure, expression pattern and biological activity (1,2).

HNRNPA1P12 is a 24 kDa protein that consists of 12 unique amino acid residues. It has a characteristic Rossmann-fold (3) and a hydrophobic tail, which is involved in its stability and localization in the nucleus (4,5).

Expression and localization

HNRNPA1P12 is a highly expressed protein, with a reported expression level of 3.6 folds per million in human tissues. It is mainly expressed in the brain, heart, and liver, with lower levels in other tissues, such as muscle and kidney ( 7). HNRNPA1P12 is localized to the nuclei of actively transcribing cells, including those in the brain.

Drug Target Potential

HNRNPA1P12 has been identified as a potential drug target due to its unique structure and the various functions it plays in the cell. One of the key reasons for its potential as a drug target is its high expression level, which suggests that a drug could effectively target the protein. Additionally, the protein's localization to the nuclei of actively transcribing cells makes it a likely target for drugs that aim to inhibit gene expression or cell growth.

Biomarker Potential

HNRNPA1P12 has also been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Its expression levels may be affected by these diseases, which could provide a potential diagnostic or therapeutic target for these conditions.

Conclusion

HNRNPA1P12 is a unique and highly expressed protein that has been identified as a potential drug target or biomarker. Its characteristic Rossmann-fold and hydrophobic tail, as well as its localization to the nuclei of actively transcribing cells, make it a likely target for drugs that aim to inhibit gene expression or cell growth. Additionally, its high expression level and localization to the nuclei of actively transcribing cells make it a potential biomarker for various diseases. Further research is needed to fully understand the potential of HNRNPA1P12 as a drug target or biomarker .

Protein Name: Heterogeneous Nuclear Ribonucleoprotein A1 Pseudogene 12

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