HMGB3: Potential Drug Targets and Biomarkers (G3149)

Target Name: HMGB3

NCBI ID: G3149

HMGB3: Potential Drug Targets and Biomarkers

High mobility group box (HMGB) proteins are a family of non-coding RNAs that play a crucial role in various cellular processes. One of the most well-known HMGB proteins is HMGB3, which is a member of the HMGB family and is expressed in various tissues throughout the body. HMGB3 has been shown to have a variety of functions, including regulating inflammation, DNA replication, and cell survival.

Despite its importance, HMGB3 has not yet been fully understood, and its potential drug targets or biomarkers are not yet well established. In this article, we will explore the potential drug targets of HMGB3 and its potential as a biomarker for various diseases.

Potential Drug Targets of HMGB3

HMGB3 has been shown to interact with a variety of protein targets, including transcription factors, DNA-binding proteins, and signaling molecules. Here are some potential drug targets for HMGB3:

1. NF-kappa-B signaling pathway

The NF-kappa-B signaling pathway is a complex network of proteins that play a role in inflammation and cellular signaling. HMGB3 has been shown to interact with the protein p65 and promote its activity, which is necessary for the NF-kappa-B signaling pathway.

2. TNF-伪 signaling pathway

TNF-伪 is a cytokine that plays a role in inflammation and cellular signaling. HMGB3 has been shown to interact with the protein FasL and promote its activity, which is necessary for the TNF-伪 signaling pathway.

3. PI3K/AKT signaling pathway

PI3K/AKT signaling pathway is a signaling pathway that plays a role in cell survival and angiogenesis. HMGB3 has been shown to interact with the protein PDGFR-尾 and promote its activity, which is necessary for the PI3K/AKT signaling pathway.

4. NF-E2F signaling pathway

The NF-E2F signaling pathway is a signaling pathway that plays a role in cell signaling and gene expression. HMGB3 has been shown to interact with the protein p16 and promote its activity, which is necessary for the NF-E2F signaling pathway.

5. Hedgehog signaling pathway

The Hedgehog signaling pathway is a signaling pathway that plays a role in cell signaling and gene expression. HMGB3 has been shown to interact with the protein Smad2 and promote its activity, which is necessary for the Hedgehog signaling pathway.

Potential Biomarkers for HMGB3

HMGB3 has been shown to have a variety of functions in various cellular processes, including regulating inflammation, DNA replication, and cell survival. As a result, HMGB3 has potential as a biomarker for various diseases. Here are some potential biomarkers for HMGB3:

1. Cancer

HMGB3 has been shown to have a role in the regulation of cancer cell survival and angiogenesis. As a result, HMGB3 has potential as a biomarker for cancer, including gastric cancer, colorectal cancer, and breast cancer.

2. Inflammatory diseases

HMGB3 has been shown to have a role in the regulation of inflammation and cellular signaling. As a result, HMGB3 has potential as a biomarker for inflammatory diseases, including rheumatoid arthritis, asthma, and diabetes.

3. Genetic disorders

HMGB3 has been shown to have a role in the regulation of cellular processes, including DNA replication and gene expression. As a result, HMGB3 has potential as a biomarker for genetic disorders, including Down syndrome, Fragile X syndrome,

Protein Name: High Mobility Group Box 3

Functions: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity)

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