HIF1A-AS3: A Potential Drug Target and Biomarker (G105370526)

Target Name: HIF1A-AS3

NCBI ID: G105370526

Other Name(s): Uncharacterized LOC105370526, transcript variant X1 | HIF1A antisense RNA 3 | LOC105370526 variant X1

HIF1A-AS3: A Potential Drug Target and Biomarker

Hemoglobin (HB) is a protein found in red blood cells (RBCs) that is responsible for carrying oxygen from the lungs to the rest of the body. The HIF1A gene, which encodes the protein HIF1A-AS3, is a key regulator of HB function and has been implicated in a variety of biological processes. HIF1A-AS3 has also been shown to play a key role in cancer development and progression, making it an attractive drug target.

The HIF1A gene was first identified in the 1990s as a key regulator of the growth and survival of human embryonic stem cells. Since then, research has continued to explore the functions of HIF1A and its associated proteins. HIF1A-AS3 is a 21-kDa protein that is expressed in a variety of tissues, including the brain, heart, kidneys, and lungs. It is composed of two distinct isoforms, HIF1A-AS3 and HIF1A-AS4, which differ in their stability and localization to different tissues.

HIF1A-AS3 is a critical regulator of cell survival and has been shown to play a key role in a variety of biological processes. One of its most well-studied functions is its role in cell stress response. When cells are exposed to stressors, such as lack of oxygen or exposure to harmful substances, HIF1A-AS3 helps to regulate the production of reactive oxygen species (ROS) and protect the cell from damage. This is accomplished through a variety of mechanisms, including the production of antioxidants, the regulation of cellular redox state, and the inhibition of pro-inflammatory pathways.

HIF1A-AS3 is also involved in the regulation of cell growth and angiogenesis. It has been shown to play a key role in the angiogenic switch, which is the process by which stem cells differentiate into functional tissues such as blood vessels. This is accomplished through the regulation of cell-cell interactions, the production of pro-migratory factors, and the inhibition of cell-extrinsic signaling pathways.

In addition to its role in cell stress response and angiogenesis, HIF1A-AS3 is also involved in the regulation of inflammation and immune responses. It has been shown to play a key role in the regulation of inflammatory cytokine production and the regulation of immune cell function . This is accomplished through the regulation of transcription factors, nuclear factors, and signaling pathways.

HIF1A-AS3 has also been shown to play a key role in the regulation of cellular metabolism and energy homeostasis. It has been shown to play a key role in the regulation of glucose uptake and utilization, fatty acid oxidation, and the regulation of mitochondrial function . This is accomplished through the regulation of insulin/IGF-1 signaling pathway, GATA-3 signaling pathway, and the regulation of nuclear transport.

Given the multiple functions of HIF1A-AS3, it is not surprising that it has been shown to be a potential drug target. Studies have shown that inhibiting the activity of HIF1A-AS3 has a variety of therapeutic potential, including the treatment of cancer, cardiovascular disease, and neurodegenerative diseases. For example, studies have shown that inhibiting the activity of HIF1A-AS3 has been shown to be effective in the treatment of breast cancer, colorectal cancer, and lung cancer.

In addition to its potential therapeutic applications, HIF1A-AS3 is also a potential biomarker for a variety of diseases. The HIF1A gene has been shown to be expressed in a variety of tissues and is involved in the regulation of a wide range of cellular processes. This makes it an attractive target for the development of biomarkers for a variety of diseases. For example, HIF1A-AS3 has been shown to be expressed in the brains of individuals with Alzheimer's disease and has been shown to play a key role in the regulation of neurodegenerative diseases.

In conclusion, HIF1A-AS3 is a protein that has been shown to play a

Protein Name: HIF1A Antisense RNA 3

More Common Targets