ACER3: Key Regulator of Cell Proliferation and Cell Death (G55331)

Target Name: ACER3

NCBI ID: G55331

ACER3: Key Regulator of Cell Proliferation and Cell Death

ACER3 (Aspartic Acid-Inducible Embryonic Response) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of cell proliferation and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the key functions of ACER3 is its role in cell proliferation. ACER3 has been shown to promote the growth and survival of various cell types, including cancer cells. It has also been shown to play a role in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases.

In addition to its role in cell proliferation, ACER3 is also involved in the regulation of cell death. It has been shown to promote the programmed cell death (apoptosis) that occurs naturally in the body, as well as the regulation of programmed cell death that occurs in response to environmental stressors, such as exposure to toxins or radiation.

The potential implications of ACER3 as a drug target or biomarker are significant. If ACER3 is found to be a useful drug target, it could lead to the development of new treatments for a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

If ACER3 is found to be a useful biomarker, it could be used to diagnose and monitor the effectiveness of existing treatments. For example, if an individual has been treated for cancer, ACER3 levels could be used to assess the effectiveness of the treatment and to identify any potential side effects.

In conclusion, ACER3 is a protein that has important roles in cell proliferation and cell death. Its potential as a drug target or biomarker make it an attractive target for research into the development of new treatments for a variety of diseases. Further studies are needed to fully understand the functions of ACER3 and its potential as a drug and biomarker.

Protein Name: Alkaline Ceramidase 3

Functions: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:20068046, PubMed:26792856, PubMed:20207939, PubMed:11356846, PubMed:30575723). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity)

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