Target Name: LMBRD1
NCBI ID: G55788
Other Name(s): LMBD1 | HDAg-L-interacting protein NESI | bA810I22.1 | liver regeneration p-53 related protein | Nuclear export signal-interacting protein | nuclear export signal-interacting protein | LMBRD1 variant 1 | Lysosomal cobalamin transport escort protein LMBD1 | LMBR1 domain containing 1, transcript variant 1 | LMBR1 domain-containing protein 1 | NESI | probable lysosomal cobalamin transporter | RP11-810I22.1 | MAHCF | OTTHUMP00000016693 | FLJ11240 | C6orf209 | cblF | Lysosomal cobalamin transport escort protein LMBD1 (isoform 1) | LMBR1 domain containing 1 | hepatitis delta antigen-L interacting protein | LMBD1_HUMAN | Probable lysosomal cobalamin transporter

Understanding The Role of LMBD1 in Diseases

LMBRD1 (LMBD1) is a gene that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. LMBD1 is a non-coding RNA molecule that has been shown to play a role in the regulation of cellular processes, including cell adhesion, migration, and survival.

The LMBD1 gene has been shown to be involved in the development and progression of various diseases, including cancer. For example, studies have shown that LMBD1 is highly expressed in cancer tissues and that it is associated with poor prognosis in cancer patients. Additionally, LMBD1 has been shown to promote the growth and survival of cancer cells, which could make it an attractive target for cancer therapies.

Another area where LMBD1 has been shown to be involved is in neurodegenerative diseases. LMBD1 has been shown to be involved in the development and progression of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Studies have shown that LMBD1 is overexpressed in the brains of individuals with these conditions and that it is associated with the severity of the disease.

In addition to its involvement in neurodegenerative diseases, LMBD1 has also been shown to be involved in psychiatric disorders. LMBD1 has been shown to be involved in the development and progression of depression and anxiety disorders. Studies have shown that LMBD1 is overexpressed in the brains of individuals with these conditions and that it is associated with the severity of the disorder.

Despite these promising findings, more research is needed to fully understand the role of LMBD1 in diseases. One approach to studying LMBD1 is to use RNA interference techniques to knockdown the expression of LMBD1 in cells and to assess the impact on cellular processes, such as cell adhesion, migration, and survival. This can help to determine if LMBD1 is involved in the development and progression of diseases.

Another approach to studying LMBD1 is to use bioinformatics tools to identify potential drug targets. This can include identifying small molecules that can interact with LMBD1 and inhibit its activity. Alternatively, researchers can use LMBD1 as a biomarker to diagnose or monitor the progression of diseases. For example, LMBD1 levels can be used as a marker for cancer and neurodegenerative diseases.

Overall, LMBD1 is a promising drug target and biomarker for a variety of diseases. Further research is needed to fully understand its role and to develop effective therapies.

Protein Name: LMBR1 Domain Containing 1

Functions: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors (PubMed:19136951). Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome (PubMed:27456980). Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity)

More Common Targets

LMBRD2 | LMCD1 | LMCD1-AS1 | LMF1 | LMF2 | LMLN | LMNA | LMNB1 | LMNB2 | LMNTD1 | LMNTD2 | LMNTD2-AS1 | LMO1 | LMO2 | LMO3 | LMO4 | LMO7 | LMO7-AS1 | LMO7DN | LMOD1 | LMOD2 | LMOD3 | LMTK2 | LMTK3 | LMX1A | LMX1B | LMX1B-DT | LNC-LBCS | LNCAROD | LNCARSR | LNCATV | LNCNEF | LNCOC1 | LNCOG | LNCPRESS1 | LNCRI | LNCRNA-ATB | LNCRNA-IUR | LNCTAM34A | LNP1 | LNPEP | LNPK | LNX1 | LNX1-AS1 | LNX2 | LOC100127946 | LOC100127955 | LOC100128002 | LOC100128028 | LOC100128050 | LOC100128059 | LOC100128079 | LOC100128093 | LOC100128164 | LOC100128242 | LOC100128288 | LOC100128317 | LOC100128361 | LOC100128398 | LOC100128494 | LOC100128593 | LOC100128770 | LOC100128966 | LOC100128988 | LOC100129034 | LOC100129098 | LOC100129148 | LOC100129175 | LOC100129203 | LOC100129215 | LOC100129316 | LOC100129381 | LOC100129434 | LOC100129455 | LOC100129534 | LOC100129603 | LOC100129697 | LOC100130000 | LOC100130207 | LOC100130285 | LOC100130298 | LOC100130331 | LOC100130452 | LOC100130463 | LOC100130548 | LOC100130587 | LOC100130691 | LOC100130698 | LOC100130744 | LOC100130748 | LOC100130872 | LOC100130899 | LOC100130938 | LOC100130987 | LOC100130992 | LOC100131096 | LOC100131107 | LOC100131257 | LOC100131289 | LOC100131372