Target Name: RBM14-RBM4
NCBI ID: G100526737
Other Name(s): Transcriptional coactivator CoAZ | transcriptional coactivator CoAZ | Paraspeckle protein 2 | Synaptotagmin-interacting protein | RBM14-RBM4 variant 1 | RRM-containing coactivator activator/modulator | COAZ | RBM14 | RBM14/RBM4 fusion | RBM14-RBM4 readthrough, transcript variant 2 | RBM14-RBM4 variant 2 | RBM14-RBM4 readthrough | RNA-binding protein 14 | Protein RBM14-RBM4 (isoform 2) | PSP2 | RNA-binding protein 14 (isoform 1) | SIP | RBM14-RBM4 readthrough, transcript variant 1 | RNA-binding motif protein 14 | SYT-interacting protein

RBM14-RBM4: A Promising Drug Target / Biomarker

The molecule RBM14-RBM4 is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of RNA-binding proteins (RBP), which are known for their ability to interact with RNA molecules. Despite its importance in various cellular processes, little is known about RBM14-RBM4. In this article, we will explore the potential drug targets and biomarkers associated with RBM14-RBM4.

Potential Drug Targets

RBM14-RBM4 has been identified as a potential drug target due to its involvement in several cellular processes. One of the main targets of RBM14-RBM4 is the interaction between this protein and RNA molecules. This interaction allows RBM14-RBM4 to regulate the translation of RNA into protein, which is a critical process for cellular growth and development.

RBM14-RBM4 has been shown to play a role in the regulation of gene expression, specifically in the regulation of stem cell proliferation. In addition, RBM14-RBM4 has been shown to interact with microRNA (miRNA) molecules, which are small non-coding RNAs that play a critical role in post-transcriptional gene regulation. This interaction between RBM14-RBM4 and miRNA molecules suggests that RBM14-RBM4 may be a useful target for drugs that are designed to modulate miRNA function.

Another potential drug target for RBM14-RBM4 is its role in the regulation of cellular stress. RBM14-RBM4 has been shown to interact with stress-responsive genes, including the stress-responsive protein p53. This interaction suggests that RBM14-RBM4 may play a role in the regulation of cellular stress responses, which could make it a useful target for drugs that are designed to modulate stress responses.

Potential Biomarkers

In addition to its potential drug targets, RBM14-RBM4 may also be a useful biomarker for certain diseases. For example, RBM14-RBM4 has been shown to be expressed in the brains of individuals with Alzheimer's disease, which is a progressive neurodegenerative disorder that is characterized by the accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain.

In addition, RBM14-RBM4 has also been shown to be involved in the regulation of cellular processes that are important for brain development and function. For example, RBM14-RBM4 has been shown to play a role in the regulation of neuron-proximal synapse formation, which is a critical process for the development and function of neurons.

Conclusion

In conclusion, RBM14-RBM4 is a protein that has been shown to play a role in various cellular processes, including the regulation of gene expression, stress responses, and neuron-proximal synapse formation. As a result, RBM14-RBM4 has potential as a drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of RBM14-RBM4 in cellular processes and its potential as a drug and biomarker.

Protein Name: RBM14-RBM4 Readthrough

Functions: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728)

More Common Targets

RBM15 | RBM15-AS1 | RBM15B | RBM17 | RBM17P1 | RBM18 | RBM19 | RBM20 | RBM22 | RBM22P1 | RBM23 | RBM24 | RBM25 | RBM26 | RBM26-AS1 | RBM27 | RBM28 | RBM3 | RBM33 | RBM34 | RBM38 | RBM39 | RBM4 | RBM41 | RBM42 | RBM43 | RBM43P1 | RBM44 | RBM45 | RBM46 | RBM47 | RBM48 | RBM48P1 | RBM4B | RBM5 | RBM5-AS1 | RBM6 | RBM7 | RBM8A | RBMS1 | RBMS1P1 | RBMS2 | RBMS2P1 | RBMS3 | RBMS3-AS3 | RBMX | RBMX2 | RBMX2P1 | RBMXL1 | RBMXL2 | RBMXL3 | RBMY1A1 | RBMY1B | RBMY1D | RBMY1F | RBMY1J | RBMY2EP | RBMY2FP | RBP1 | RBP2 | RBP3 | RBP4 | RBP5 | RBP7 | RBPJ | RBPJL | RBPJP2 | RBPMS | RBPMS-AS1 | RBPMS2 | RBSN | RBX1 | RC3H1 | RC3H2 | RCAN1 | RCAN2 | RCAN3 | RCAN3AS | RCBTB1 | RCBTB2 | RCC1 | RCC1L | RCC2 | RCCD1 | RCE1 | RCHY1 | RCL1 | RCN1 | RCN1P2 | RCN2 | RCN3 | RCOR1 | RCOR2 | RCOR3 | RCSD1 | RCVRN | RD3 | RD3L | RDH10 | RDH11