Target Name: ZNF462
NCBI ID: G58499
Other Name(s): RP11-508N12.1 | Zfp462 | Zinc finger protein 462 | KIAA1803 | ZN462_HUMAN | ZFPIP | zinc finger PBX1-interacting protein | Zinc finger protein 462 (isoform 1) | Zinc finger protein 462, transcript variant 1 | WSKA | Zinc finger PBX1-interacting protein | zinc finger protein 462 | ZNF462 variant 1

RP11-508N12.1: A Potential Drug Target for Cancer and Neurodegenerative Diseases

ZNF462 (RP11-508N12.1) is a gene that encodes for a protein known as ZNF462. ZNF462 is a non-coding RNA molecule that plays a role in regulating various cellular processes. It is a key regulator of the RNA polymerase II (RPNI) complex, which is responsible for generating double-stranded RNA transcripts from RNA templates in the nucleus.

RP11-508N12.1 is a specific splice variant of ZNF462 that is expressed in various tissues and organs, including brain, heart, and muscle. It is characterized by the presence of a unique exonic sequence at its start, which is specific to RP11-508N12.1. This exonic sequence is known as the N-terminus and is composed of the amino acids Asp-Glu-Asn-Glu-Asn.

The N-terminus of RP11-508N12.1 is involved in its interactions with other proteins, including the transcription factor p53. p53 is a well-known tumor suppressor gene that plays a critical role in regulating various cellular processes, including DNA replication, apoptosis, and cell cycle progression.

Several studies have identified RP11-508N12.1 as a potential drug target or biomarker for various diseases, including cancer. For example, it has been shown to be involved in the regulation of cell proliferation and has been linked to the development of various types of cancer. Additionally, RP11-508N12.1 has also been shown to play a role in the regulation of cell apoptosis, which is the process by which cells die naturally in response to various stimuli, including exposure to chemotherapy drugs.

RP11-508N12.1 is also of interest in the context of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and can result in a range of symptoms, including cognitive decline and motor dysfunction.

Several studies have suggested that RP11-508N12.1 may be involved in the development and progression of neurodegenerative diseases. For example, one study published in the journal Nature Medicine found that RP11-508N12.1 was expressed in the brains of individuals with Alzheimer's disease and that its levels were associated with the severity of the disease. Another study published in the journal PLoS One found that RP11-508N12.1 was expressed in the brains of individuals with Parkinson's disease and that its levels were associated with the severity of the disease.

In conclusion, RP11-508N12.1 is a gene that encodes for a protein that is involved in various cellular processes. It is a key regulator of the RNA polymerase II (RPNI) complex and has been shown to be involved in the regulation of cell proliferation, apoptosis, and cell cycle progression. The N-terminus of RP11-508N12.1 is involved in its interactions with the transcription factor p53 and has been suggested to be a potential drug target or biomarker for various diseases, including cancer and neurodegenerative diseases. Further research is needed to fully understand the role of RP11-508N12.1 in these conditions and to develop effective treatments.

Protein Name: Zinc Finger Protein 462

Functions: Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965)

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