CPLX3: A Protein with Potential as A Drug Target and Biomarker

Target Name: CPLX3

NCBI ID: G594855

CPLX3: A Protein with Potential as A Drug Target and Biomarker

CPLX3 (Nbla11589) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Nbla family of proteins, which are involved in the regulation of neural stem cell proliferation and differentiation.

One of the unique features of CPLX3 is its ability to interact with several different proteins, including the transcription factor p53. This interaction allows CPLX3 to regulate the activity of p53 and to play a role in the regulation of cellular processes such as cell growth, apoptosis, and inflammation.

In addition to its role in cellular regulation, CPLX3 has also been shown to play a key role in the development and progression of several diseases, including cancer. For example, studies have shown that high levels of CPLX3 are associated with poor prognosis in patients with pancreatic cancer, and that inhibition of CPLX3 has been shown to be a promising approach for the treatment of this disease.

Due to its potential role in the regulation of cellular processes and its association with several diseases, CPLX3 has generated a lot of interest as a drug target. Researchers are actively searching for small molecules that can inhibit the activity of CPLX3 and are exploring these compounds as potential new treatments for a variety of diseases.

In addition to its potential as a drug target, CPLX3 is also being investigated as a biomarker for several diseases. For example, studies have shown that CPLX3 levels can be used as a diagnostic marker for pancreatic cancer, and that these levels can also be used to monitor the effectiveness of anti-cancer treatments.

Overall, CPLX3 is a protein that has significant potential as a drug target and as a biomarker for several diseases. Further research is needed to fully understand its role in cellular processes and its potential as a therapeutic agent.

Protein Name: Complexin 3

Functions: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity)

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