HSPD1P9: A Potential Drug Target and Biomarker (G646910)

Target Name: HSPD1P9

NCBI ID: G646910

Other Name(s): HSPD1-14P | heat shock protein family D (Hsp60) member 1 pseudogene 9 | Heat shock protein family D (Hsp60) member 1 pseudogene 9

HSPD1P9: A Potential Drug Target and Biomarker

Human sulfate protease (HSPD1P9) is a protein widely expressed in many cells and tissues, including liver, spleen, bone marrow and kidney. The sulfatase family includes 14 subtypes, of which HSPD1P9 is the most commonly used genotype. HSPD1P9 plays important biological functions in cells, such as cell proliferation, apoptosis, antigen presentation and immune response. In recent years, studies have found that HSPD1P9 has potential application value in liver disease, kidney disease, neurodegenerative diseases, etc., and therefore has received widespread attention. This article will discuss the structure, function, potential as a drug target and application as a biomarker of HSPD1P9.

1. Structure

HSPD1P9 is a single-chain, acidic protein with a molecular weight of approximately 40 kDa. HSPD1P9 has a highly conserved amino acid sequence, including a conserved 伪-helix, a conserved 尾-sheet and a conserved 纬-helix. The extracellular structure of HSPD1P9 mainly consists of three domains: core domain, transmembrane region and extracellular domain.

2. Function

HSPD1P9 plays an important role in many biological processes, including cell proliferation, apoptosis, antigen presentation and immune response. HSPD1P9 plays a key role in cell proliferation. During mitosis, HSPD1P9 participates in chromosome structural stability and intracellular transport, thereby regulating cell proliferation. HSPD1P9 plays a key role in apoptosis. Studies have found that HSPD1P9 plays an important role in liver cell apoptosis, and liver cell apoptosis is an important process in the occurrence and development of liver diseases. HSPD1P9 plays a key role in antigen presentation. HSPD1P9 is a key molecule in the interaction between PD-L1 and PD-L1R and plays an important role in cellular immune response.

3. Potential as a drug target

1. Treat liver disease

Liver disease is a common disease, such as cirrhosis, liver cancer, etc. The occurrence and development of liver diseases are closely related to the dysfunction of HSPD1P9. Studies have found that HSPD1P9 plays an important role in liver disease and can be used as a potential drug target. At present, some drugs, such as bevacizumab, Alisca, etc., have entered the clinical trial stage for the treatment of liver diseases. HSPD1P9 has good application prospects as a drug target.

2. Treat kidney disease

Kidney disease is a common disease, such as diabetic nephropathy, nephritis, etc. The occurrence and development of kidney disease are closely related to the dysfunction of HSPD1P9. Studies have found that HSPD1P9 plays an important role in kidney disease and can be used as a potential drug target. At present, some drugs, such as Ivecona, rallopril, etc., have entered the clinical trial stage for the treatment of kidney diseases. HSPD1P9 has good application prospects as a drug target.

3. Treat neurodegenerative diseases

Neurodegenerative diseases are common diseases, such as Parkinson's disease, Alzheimer's disease, etc. The occurrence and development of neurodegenerative diseases are closely related to the dysfunction of HSPD1P9. Studies have found that HSPD1P9 plays an important role in neurodegenerative diseases and can be used as a potential drug target. Currently, some drugs, such as levodopa and amnesia drugs, have entered clinical trials for the treatment of neurodegenerative diseases. HSPD1P9 has good application prospects as a drug target.

4. Application as biomarker

HSPD1P9 plays an important role in many biological processes and therefore can be used as a potential biomarker. The expression level of HSPD1P9 can be used as a biomarker for liver disease, kidney disease and neurodegenerative diseases. In addition, the expression level of HSPD1P9 can also be used as a biological indicator of drug efficacy.

Protein Name: Heat Shock Protein Family D (Hsp60) Member 1 Pseudogene 9

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