Regulation of Immune and Cell Signaling By ZNHIT2 (G741)

Target Name: ZNHIT2

NCBI ID: G741

Regulation of Immune and Cell Signaling By ZNHIT2

Zinc finger hits (ZFHs) are a family of non-coding RNAs that play a central role in post-transcriptional gene regulation. ZNHIT2, also known as Zinc finger HIT-type containing 2, is a ZFH that has been shown to regulate gene expression in various organisms, including humans.

The ZFH family of non-coding RNAs consists of several subfamilies, including ZFH1, ZFH2, and ZFH3. ZFH1, also known as HIT-like 1, is a ZFH that contains a nucleotide-binding oligomerization domain (NBO), which is responsible for binding to specific DNA sequences. ZFH2, also known as HIT-like 2, is a ZFH that contains a nucleotide-binding oligomerization domain and a zinc finger domain (ZNF), which is responsible for the formation of ZFHs. ZFH3, also known as HIT-like 3, is a ZFH that contains a nucleotide-binding oligomerization domain and a zinc finger domain, but it does not have a ZNF.

ZNHIT2 is a ZFH that contains a nucleotide-binding oligomerization domain and a zinc finger domain, similar to ZFH2. It has been shown to regulate gene expression in various organisms, including humans.

One of the functions of ZNHIT2 is to regulate the expression of genes involved in the immune system. For example, ZNHIT2 has been shown to regulate the expression of genes involved in the production of antibodies, which are important for the immune response.

Another function of ZNHIT2 is to regulate the expression of genes involved in cell signaling pathways. For example, ZNHIT2 has been shown to regulate the expression of genes involved in the production of neurotransmitters, which are important for cellular signaling.

In addition to its functions in regulating gene expression, ZNHIT2 is also a potential drug target. The ZNF domain of ZNHIT2 has been shown to be a potential drug target, as it contains a zinc ion that can be stabilized by drugs and can interact with other molecules to alter their activity.

Overall, ZNHIT2 is a ZFH that has been shown to regulate gene expression in various organisms, including humans. Its function in regulating the immune system and cell signaling pathways makes it a potential drug target. Further research is needed to fully understand the role of ZNHIT2 in biology and its potential as a drug.

Protein Name: Zinc Finger HIT-type Containing 2

Functions: May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (PubMed:28561026). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (PubMed:28561026). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026)

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