Target Name: NUP214
NCBI ID: G8021
Other Name(s): D9S46E | Nucleoporin 214kD (CAIN) | CAIN | NUP214 variant 2 | CAN protein, putative oncogene | Nuclear pore complex protein Nup214 | MGC104525 | Nucleoporin Nup214 | IIAE9 | N214 | Protein CAN | nucleoporin 214kDa | p250 | Nuclear pore complex protein Nup214 (isoform 2) | CAN | 214 kDa nucleoporin | nucleoporin 214 | Nucleoporin 214, transcript variant 2 | NU214_HUMAN

NUP214: A Protein Involved in Stem Cell and Cell Death Regulation

NUP214 (D9S46E) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Nup family of proteins, which are known for their role in regulating gene expression and cell signaling. NUP214 has been shown to play a role in the regulation of cellular processes that are important for both normal development and disease.

One of the key functions of NUP214 is its role in the regulation of stem cell proliferation. Stem cells are a type of cell that have the ability to develop into any type of cell in the body, and they play a crucial role in the development and maintenance of tissues and organs. NUP214 has been shown to be involved in the regulation of stem cell proliferation by mechanisms such as the inhibition of the activity of the transcription factor SMAD.

NUP214 has also been shown to play a role in the regulation of cell death. Cell death, also known as apoptosis, is an important part of the natural regulation of cell life cycle, and it is critical for the development and maintenance of tissues and organs. NUP214 has been shown to be involved in the regulation of cell death by mechanisms such as the inhibition of the activity of the protein p53, which is a well-known regulator of apoptosis.

In addition to its role in stem cell proliferation and cell death, NUP214 has also been shown to play a role in the regulation of cellular signaling pathways. NUP214 is a component of several signaling pathways that are involved in the regulation of cellular processes, including the regulation of cell adhesion, the regulation of the blood-brain barrier, and the regulation of inflammation.

Due to its involvement in a wide range of cellular processes, NUP214 has been identified as a potential drug target. Researchers are currently working to develop NUP214-based therapies for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The development of NUP214-based therapies has the potential to revolutionize the field of pharmacology, as it may provide new treatments for a wide range of diseases.

In conclusion, NUP214 is a protein that is involved in a wide range of cellular processes that are important for both normal development and disease. Its potential as a drug target makes it an attractive target for the development of new therapies for a variety of diseases. Further research is needed to fully understand the role of NUP214 in cellular processes and its potential as a drug target.

Protein Name: Nucleoporin 214

Functions: Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440)

More Common Targets

NUP35 | NUP37 | NUP42 | NUP43 | NUP50 | NUP50-DT | NUP54 | NUP58 | NUP62 | NUP62CL | NUP85 | NUP88 | NUP93 | NUP98 | NUPR1 | NUPR2 | NUS1 | NUS1P1 | NUS1P3 | NUSAP1 | NUTF2 | NUTF2P4 | NUTM1 | NUTM2A | NUTM2A-AS1 | NUTM2B | NUTM2B-AS1 | NUTM2D | NUTM2E | NUTM2F | NUTM2G | NVL | NWD1 | NWD2 | NXF1 | NXF2 | NXF3 | NXF4 | NXF5 | NXN | NXNL1 | NXNL2 | NXPE1 | NXPE2 | NXPE3 | NXPE4 | NXPH1 | NXPH2 | NXPH3 | NXPH4 | NXT1 | NXT2 | NXTAR | NYAP1 | NYAP2 | NYNRIN | NYX | OACYLP | OAF | OARD1 | OAS1 | OAS2 | OAS3 | OASL | OAT | OATP1 | OAZ1 | OAZ2 | OAZ3 | OBI1 | OBI1-AS1 | OBP2A | OBP2B | OBSCN | OBSCN-AS1 | OBSL1 | OC90 | OCA2 | OCEL1 | OCIAD1 | OCIAD2 | OCLM | OCLN | OCLNP1 | OCM | OCM2 | OCRL | OCSTAMP | ODAD1 | ODAD2 | ODAD3 | ODAD4 | ODAM | ODAPH | ODC1 | ODCP | ODF1 | ODF2 | ODF2L | ODF3