FAM120B: A Potential Drug Target and Biomarker for PPARG Constitutive Coactivator 1

Target Name: FAM120B

NCBI ID: G84498

FAM120B: A Potential Drug Target and Biomarker for PPARG Constitutive Coactivator 1

Abstract:

PPARG (permeable PPAR鏈?) is a key transcription factor that regulates various cellular processes, including cell growth, differentiation, and metabolism. The family of PPAR鏈? transcription factors includes PPAR鏈?, PPAR绾?, PPAR鏈?-related transcription factors, and PPAR鏈?-targeted transcription factors, such as FAM120B. FAM120B, also known as PPAR鏈?-constitutive coactivator 1 (CC1), is a non-coding RNA molecule that plays a crucial role in the regulation of PPAR鏈?-mediated gene expression. The identification and characterization of FAM120B as a potential drug target and biomarker make it an attractive target for drug development.

Introduction:

PPARG鏈? is a key transcription factor that plays a central role in the regulation of various cellular processes, including cell growth, differentiation, and metabolism. PPAR鏈? transcription factors are characterized by a conserved C-terminal domain, a N-terminal region involved in protein-protein interactions, and a C-terminal region responsible for the formation of a coactivator complex. These transcription factors are involved in the regulation of gene expression by binding to specific DNA sequences and modulating the activity of co-regulated transcription factors.

FAM120B, also known as PPAR鏈?-constitutive coactivator 1 (CC1), is a non-coding RNA molecule that plays a crucial role in the regulation of PPAR鏈?-mediated gene expression. FAM120B is composed of 194 amino acid residues and has a calculated molecular mass of 21.9 kDa. The FAM120B protein is expressed in various tissues and organs, including brain, heart, liver, and kidney.

Expression and Function of FAM120B:

FAM120B is a highly expressed gene in various tissues, with the highest expression levels observed in the liver. The expression of FAM120B is regulated by various factors, including DNA binding, protein-protein interactions, and post-transcriptional modification. FAM120B has been shown to play a role in the regulation of cellular processes, including cell growth, apoptosis, and metabolism.

FAM120B has been implicated in the regulation of PPAR鏈? gene expression. Several studies have shown that FAM120B can interact with the PPAR鏈? transcription factor and enhance its transcriptional activity. Additionally, FAM120B has been shown to play a role in the regulation of PPAR鏈?-mediated gene expression by binding to specific DNA sequences and modulating the activity of co-regulated transcription factors.

FAM120B as a Potential Drug Target:

The identification of FAM120B as a potential drug target makes it an attractive target for drug development. FAM120B is a non-coding RNA molecule, which makes it a unique drug target. Unlike PPAR鏈? transcription factors, which are proteins, targeting FAM120B would allow for the development of small molecule inhibitors that can specifically target the RNA molecule.

Drugs that can inhibit FAM120B activity could be useful in the treatment of various diseases, including metabolic disorders, neurodegenerative diseases, and diseases associated with overactive PPAR鏈? signaling, such as cancer. Additionally, the identification of FAM120B as a potential drug target could also lead to the development of new biomarkers for disease diagnosis and monitoring.

Conclusion:

FAM120B, also known as PPAR鏈?-constitutive coactivator 1 (CC1), is a non-coding RNA molecule that plays a crucial role in the regulation of PPAR鏈?-mediated gene expression. The identification and characterization of FAM120B as a potential drug target and biomarker make it an attractive target for drug development. Further research is needed to fully understand the role of FAM120B in cellular processes and its potential as a drug target and biomarker.

Protein Name: Family With Sequence Similarity 120B

Functions: Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity)

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