Target Name: TNFSF13
NCBI ID: G8741
Other Name(s): a proliferation-inducing ligand | TNFSF13 variant zeta | APRIL | TWE-PRIL | tumor necrosis factor (ligand) superfamily, member 13 | TNF superfamily member 13 | TNFSF13 variant beta | TALL2 | UNQ383/PRO715 | Tumor necrosis factor ligand superfamily member 13 (isoform eta) | ZTNF2 | Tumor necrosis factor ligand superfamily member 13 (isoform gamma) | TNF superfamily member 13, transcript variant eta | Tumor necrosis factor ligand superfamily member 13 (isoform beta) | Tumor necrosis factor ligand superfamily member 13 (isoform zeta) | sAPRIL_(HUMAN) | TNF superfamily member 13, transcript variant alpha | TNF-related death ligand-1 (TRDL-1) | Tumor necrosis factor ligand superfamily member 13 (isoform delta) | tumor necrosis factor ligand 7B | TNF13_HUMAN | CD256 | tumor necrosis factor-like protein ZTNF2 | TRDL-1 | Tumor necrosis factor ligand superfamily member 13 , soluble form | TNF superfamily member 13, transcript variant zeta | TNLG7B | tumor necrosis factor-related death ligand-1 | TNFSF13 variant eta | A proliferation-inducing ligand | Tumor necrosis factor ligand superfamily member 13 (isoform alpha) | TNF-related death ligand 1 | Tumor necrosis factor ligand superfamily member 13 | tumor necrosis factor superfamily member 13 | TNFSF13 variant gamma | Tumor necrosis factor superfamily member 13, transcript variant beta | Tumor necrosis factor superfamily member 13, transcript variant gamma | A proliferation-inducing ligand (APRIL) | TALL-2 | TNF-and APOL-related leukocyte expressed ligand 2 (TALL-2) | Tumor necrosis factor superfamily member 13, transcript variant delta | TNFSF13 variant alpha | TNF- and APOL-related leukocyte expressed ligand 2 | soluble APRIL_(HUMAN) | TNFSF13 variant delta

TNFSF13: A Potential Drug Target and Biomarker for Proliferation Inhibition

Introduction

Proliferation is a critical process in many organisms, including humans. The uncontrolled growth of cells can lead to the development of various diseases, such as cancer, neurodegenerative disorders, and autoimmune diseases. To prevent this uncontrolled growth, scientists have identified various signaling pathways that regulate cell proliferation. One such pathway is the transforming growth factor-TGF-β pathway.

The TNFSF13 gene, which encodes a protein called transforming growth factor receptor-TGFR-尾, is a key regulator of the TGF-β pathway. This gene has been implicated in various cellular processes, including cell proliferation, differentiation, and survival. The TGF -尾 pathway plays a crucial role in the development and maintenance of tissues, and it is often dysregulated in many diseases, including cancer.

TNFSF13 as a Drug Target

The TNFSF13 gene has been identified as a potential drug target for the treatment of various diseases due to its involvement in the TGF-β pathway. The development of compounds that can inhibit the activity of TNFSF13 has the potential to be a new therapeutic approach for the treatment of diseases that are characterized by uncontrolled cell growth, including cancer, neurodegenerative disorders, and autoimmune diseases.

One of the key advantages of targeting TNFSF13 is its specificity to the TGF-β pathway. This allows for the development of compounds that can specifically inhibit the activity of TNFSF13 and its downstream targets, such as the Smad family proteins. Additionally, the TGF- 尾 pathway is a well-established target for drug development, and many inhibitors that have been developed for the TGF-β pathway have been approved for use in clinical trials.

TNFSF13 as a Biomarker

In addition to its potential as a drug target, TNFSF13 has also been identified as a potential biomarker for the diagnosis and monitoring of various diseases. The TGF-β pathway is involved in the development and maintenance of many tissues, including bones, skin, heart , and neural tissues. The Smad family proteins that are downstream targets of TNFSF13 have been shown to be involved in the regulation of cell growth, differentiation, and survival.

Therefore, the levels of TNFSF13 and its downstream targets can be used as biomarkers for the diagnosis and monitoring of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. The development of biomarkers for these diseases can provide valuable information for the diagnosis and treatment of these conditions.

Conclusion

TNFSF13 is a gene that has been implicated in various cellular processes, including cell proliferation and the TGF-β pathway. The development of compounds that can inhibit the activity of TNFSF13 has the potential to be a new therapeutic approach for the treatment of diseases characterized by uncontrolled cell growth, including cancer, neurodegenerative disorders, and autoimmune diseases. Additionally, the levels of TNFSF13 and its downstream targets can be used as biomarkers for the diagnosis and monitoring of these diseases. Further research is needed to develop new compounds and to understand the full role of TNFSF13 in these processes.

Protein Name: TNF Superfamily Member 13

Functions: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes

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TNFSF13B | TNFSF14 | TNFSF15 | TNFSF18 | TNFSF4 | TNFSF8 | TNFSF9 | TNIK | TNIP1 | TNIP2 | TNIP2P1 | TNIP3 | TNK1 | TNK2 | TNK2-AS1 | TNKS | TNKS1BP1 | TNKS2 | TNMD | TNN | TNNC1 | TNNI1 | TNNI2 | TNNI3 | TNNI3K | TNNT1 | TNNT2 | TNNT3 | TNP1 | TNP2 | TNPO1 | TNPO2 | TNPO3 | TNR | TNRC17 | TNRC18 | TNRC18P1 | TNRC6A | TNRC6B | TNRC6C | TNS1 | TNS1-AS1 | TNS2 | TNS2-AS1 | TNS3 | TNS4 | TNXA | TNXB | TOB1 | TOB1-AS1 | TOB2 | TOB2P1 | TODL | TOE1 | TOGARAM1 | TOGARAM2 | Toll-Like Receptor | TOLLIP | TOLLIP-DT | Tolloid-like protein | TOM complex | TOM1 | TOM1L1 | TOM1L2 | TOMM20 | TOMM20L | TOMM20P2 | TOMM22 | TOMM34 | TOMM40 | TOMM40L | TOMM40P2 | TOMM5 | TOMM6 | TOMM7 | TOMM70 | Tomoregulin | TONSL | TONSL-AS1 | TOP1 | TOP1MT | TOP1P1 | TOP1P2 | TOP2A | TOP2B | TOP3A | TOP3B | TOP3BP1 | TOPAZ1 | TOPBP1 | TOPORS | TOR1A | TOR1AIP1 | TOR1AIP2 | TOR1B | TOR2A | TOR3A | TOR4A | TOX | TOX2