HERC2: A Protein Potential Drug Target (G8924)

Target Name: HERC2

NCBI ID: G8924

HERC2: A Protein Potential Drug Target

HERC2 (p528) is a protein that is expressed in various tissues throughout the body, including the lungs, heart, liver, and brain. It is a member of the HERC family of transmembrane proteins, which are known for their role in intracellular signaling.

One of the most significant functions of HERC2 is its role in the regulation of cell signaling pathways. Specifically, HERC2 has been shown to play a key role in the regulation of the NF-kappa-B signaling pathway, which is a complex process that involved in the regulation of various cellular processes, including inflammation, cell growth, and differentiation.

In addition to its role in cell signaling, HERC2 has also been shown to play a number of important roles in the regulation of cellular processes that are critical for maintaining tissue homeostasis. For example, HERC2 has been shown to play a key role in the regulation of blood pressure, as well as the regulation of bone density and muscle mass.

Given its importance for a wide range of cellular processes, it is not surprising that HERC2 has also been identified as a potential drug target. Researchers have been investigating the potential therapeutic benefits of targeting HERC2, with the goal of using this protein to treat a variety of diseases and conditions.

One of the most promising approaches to targeting HERC2 is the use of small molecules, such as drugs that can inhibit the activity of HERC2. These small molecules have been shown to be effective in a variety of cellular models, including cell signaling pathways and other cellular processes.

Another approach to targeting HERC2 is the use of monoclonal antibodies, which are laboratory-produced proteins that are designed to recognize and bind to specific proteins. Monoclonal antibodies have been shown to be highly effective in targeting HERC2, and have been used in a variety of cellular models to inhibit the activity of this protein.

In addition to these approaches, researchers have also been exploring the use of genetic modification to modify the expression of HERC2. This technique allows researchers to introduce changes to the DNA sequence of an organism, which can affect the expression of various proteins, including HERC2.

Overall, HERC2 is a protein that has the potential to be a drug target or biomarker. Its role in the regulation of cell signaling pathways and its importance for maintaining tissue homeostasis make it an attractive target for researchers to explore. Further studies are needed to fully understand the potential of HERC2 as a drug target or biomarker.

Protein Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2

Functions: E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)

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