ZNF585B: A Potential Drug Target and Biomarker (G92285)
ZNF585B: A Potential Drug Target and Biomarker
ZNF585B (SZFP41), a protein that belongs to the Zinc Finger Nucleotide (ZNF) family, plays a crucial role in the development and maintenance of various tissues, including brain, heart, and cancer. ZNF585B has been identified as a potential drug target and biomarker due to its unique structure, function, and involvement in several disease processes.
The ZNF family consists of several proteins that contain a characteristic ZNF-specific domain and a nucleotide-binding oligomerization (NBO) domain. ZNF585B is a 21-kDa protein that is expressed in various tissues, including brain, heart, liver, and cancer ( 1). It is composed of a 166 amino acid residue N-terminal region, a 21 amino acid residue ZNF-specific domain, a 48 amino acid residue NBO domain, and a 122 amino acid residue C-terminal region.
The ZNF-specific domain is a unique feature that is found in all ZNF proteins. It is composed of a nucleotide-binding oligomerization (NBO) domain that consists of a variable number of nucleotide-binding modules (NBMs). The NBMs are responsible for the interaction of the protein with specific nucleotides, which is essential for its function. The ZNF-specific domain is involved in the regulation of DNA replication, gene expression, and cell growth.
The NBO domain is another unique feature that is found in all ZNF proteins. It is composed of a series of parallel beta-helices that are responsible for the formation of a distinct secondary structure(5). The NBO domain is involved in the regulation of protein-protein and protein-DNA interactions and has been implicated in various diseases, including cancer.
Several studies have suggested that ZNF585B may be a drug target due to its involvement in various diseases, including cancer. For instance, ZNF585B has been shown to be involved in the regulation of cell growth, angiogenesis, and drug resistance in cancer cells. Additionally, ZNF585B has been shown to play a role in the development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.
In addition to its potential as a drug target, ZNF585B has also been identified as a biomarker for several diseases. For instance, ZNF585B has been shown to be involved in the diagnosis of cancer, including breast, ovarian, and prostate cancers. Additionally, ZNF585B has been shown to be involved in the diagnosis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.
In conclusion, ZNF585B is a protein that has been identified as a potential drug target and biomarker due to its unique structure, function, and involvement in several disease processes. Further research is needed to fully understand the role of ZNF585B in disease progression and the development of new treatments.
Protein Name: Zinc Finger Protein 585B
Functions: May be involved in transcriptional regulation
More Common Targets
ZNF586 | ZNF587 | ZNF587B | ZNF589 | ZNF592 | ZNF593 | ZNF594 | ZNF594-DT | ZNF595 | ZNF596 | ZNF597 | ZNF598 | ZNF599 | ZNF600 | ZNF603P | ZNF605 | ZNF606 | ZNF607 | ZNF608 | ZNF609 | ZNF610 | ZNF611 | ZNF613 | ZNF614 | ZNF615 | ZNF616 | ZNF618 | ZNF619 | ZNF620 | ZNF621 | ZNF622 | ZNF623 | ZNF624 | ZNF625 | ZNF625-ZNF20 | ZNF626 | ZNF627 | ZNF628 | ZNF629 | ZNF630 | ZNF638 | ZNF639 | ZNF641 | ZNF644 | ZNF646 | ZNF648 | ZNF649 | ZNF652 | ZNF652-AS1 | ZNF653 | ZNF654 | ZNF655 | ZNF658 | ZNF658B | ZNF66 | ZNF660 | ZNF662 | ZNF663P | ZNF664 | ZNF664-RFLNA | ZNF665 | ZNF667 | ZNF667-AS1 | ZNF668 | ZNF669 | ZNF670 | ZNF670-ZNF695 | ZNF671 | ZNF672 | ZNF674 | ZNF674-AS1 | ZNF675 | ZNF676 | ZNF677 | ZNF678 | ZNF679 | ZNF680 | ZNF681 | ZNF682 | ZNF683 | ZNF684 | ZNF687 | ZNF688 | ZNF689 | ZNF69 | ZNF691 | ZNF692 | ZNF695 | ZNF696 | ZNF697 | ZNF699 | ZNF7 | ZNF70 | ZNF700 | ZNF701 | ZNF702P | ZNF703 | ZNF704 | ZNF705A | ZNF705B
