P200, A Potential Drug Target and Biomarker for Various Diseases

Target Name: Proteasome 20S

NCBI ID: P13009

Other Name(s): 20S Core | 20S core particle

P200, A Potential Drug Target and Biomarker for Various Diseases

Proteasome 20S (20S Core), also known as P200, is a protein that is found in the endoplasmic reticulum (ER) and is involved in the regulation of protein interactions and degradation. P200 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The 20S Core is a subunit of the proteasome, which is a complex protein that plays a crucial role in regulating protein synthesis in the cell. The proteasome is composed of a large protein known as the 20S subunit and smaller proteins known as the 6.2S and 17S subunits. The 20S subunit is responsible for recognizing and interacting with target proteins, which are then degraded in the cytosol.

P200 is a 20S subunit that contains a unique N-terminus and a unique C-terminus. The N-terminus of P200 contains a nucleotide acid sequence that is similar to the active site of the proteasome, which suggests that it may be involved in protein -protein interactions that regulate the activity of the proteasome. The C-terminus of P200 contains a unique glycine residue, which is also known as a glycine tail, which is involved in protein-protein interactions and may be a potential binding site for small molecules or other proteins.

P200 has been shown to play a role in the regulation of protein interactions and degradation in various cell types. For example, studies have shown that P200 can interact with the protein known as N-terminal-pro-Q2 (N-Q2), which is a component of the endoplasmic reticulum-associated protein (ER-associated protein) family. N-Q2 is a transmembrane protein that is involved in the regulation of protein folding and degradation, and it has been shown to interact with various proteins, including P200.

In addition to its role in protein-protein interactions, P200 has also been shown to play a role in the regulation of protein degradation. Studies have shown that P200 can interact with the protein known as calbindin, which is a calcium-binding protein that is involved in the regulation of protein stability and degradation. Calbindin has been shown to interact with P200 and can enhance the degradation of various proteins, including the protein known as p53, which is a well-known tumor suppressor protein.

P200 has also been shown to play a role in the regulation of protein synthesis and translation. Studies have shown that P200 can interact with the protein known as translation factor 1 (TF-1), which is a protein that is involved in the regulation of protein synthesis and translation. TF-1 has been shown to interact with P200 and can enhance the stability of various proteins, including the protein known as ribosomal subunit alpha (rRNA), which is a component of the ribosome.

In conclusion, P200 is a protein that is involved in the regulation of protein interactions and degradation. It has been shown to interact with various proteins, including N-Q2, calbindin, and TF-1. Its unique N-terminus and C-terminus , as well as its ability to enhance the degradation of various proteins, make it a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of P200 in the regulation of protein interactions and degradation.

Protein Name: Proteasome 20S

More Common Targets