The 26S Proteasome Complex: A Protein-Protein Interaction Network Regulating Protein Degradation

Target Name: Proteasome Complex

NCBI ID: P13024

Other Name(s): 26S proteasome complex | 26S proteasome | Proteasome

The 26S Proteasome Complex: A Protein-Protein Interaction Network Regulating Protein Degradation

The Proteasome Complex (26S proteasome complex) is a protein-protein interaction network that plays a crucial role in regulating protein degradation in eukaryotic cells. It is composed of 26 different protein subunits that are involved in the degradation of various cellular proteins. The 26S proteasome complex is a key player in the regulation of cell signaling pathways, and it is also a potential drug target in the treatment of various diseases.

The 26S proteasome complex is a protein-protein interaction network that consists of 26 different protein subunits that are involved in the degradation of various cellular proteins. The complex is composed of three subunits that are known as the 26S ATP-binding subunit (APS), the 26S GTP-binding subunit (GAP), and the 26S non-ATP-binding subunit (NPB). The APS and GAP subunits form the core of the network and are responsible for the regulation of protein degradation, while the NPB subunit provides a structural framework for the complex.

The 26S proteasome complex plays a crucial role in the regulation of cell signaling pathways. It is involved in the degradation of a wide variety of proteins, including cytoskeletal components, transcription factors, and signaling proteins. The complex is also involved in the regulation of cellular processes such as cell division, apoptosis, and autophagy.

One of the key functions of the 26S proteasome complex is the regulation of protein degradation. It is involved in the degradation of proteins that are no longer needed or that have become damaged. This is important for maintaining cellular homeostasis and for the regulation of various cellular processes. The 26S proteasome complex is also involved in the regulation of protein synthesis by ensuring that the cell has access to the necessary tools for protein synthesis.

The 26S proteasome complex is a potential drug target in the treatment of various diseases. Many diseases, including cancer, neurodegenerative diseases, and autoimmune diseases, are characterized by the over-expression or dysfunction of various signaling proteins. The 26S proteasome complex is involved in the regulation of many of these signaling pathways, and it is potential to be targeted with drugs that can inhibit its activity.

In conclusion, the 26S proteasome complex is a protein-protein interaction network that plays a crucial role in regulating protein degradation in eukaryotic cells. It is a potential drug target in the treatment of various diseases due to its involvement in the regulation of cellular signaling pathways. Further research is needed to fully understand the mechanisms of the 26S proteasome complex and its potential as a drug target.

Protein Name: Proteasome Complex

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