Regulation of Protein Synthesis in Eukaryotic Cells (P16365)

Target Name: Adaptor-related protein complex 2

NCBI ID: P16365

Other Name(s): AP2 adaptor complex | AP2 | AP-2 complex

Regulation of Protein Synthesis in Eukaryotic Cells

Adaptor-related protein complex 2 (AP2) is a protein complex that plays a crucial role in the process of protein synthesis in eukaryotic cells. It is composed of multiple adapter proteins that form a highly stable complex with each other. One of the adapters in This complex is known as AP2, which is a key regulator of the initiation of the translation of mRNAs.

The AP2 adapter complex is a protein-protein interaction (PPI) domain that contains multiple distinct protein subunits. The complex is composed of the following subunits: AP2, AP3, AP4, and AP5. These subunits are held together by various interactions, including ionic bonds, hydrogen bonds, and van der Waals forces. The complex has a highly stoichiometric composition, with each subunit contributing a specific function to the overall structure and stability of the complex.

One of the key functions of the AP2 adapter complex is to regulate the rate of protein synthesis in the cell. This is accomplished through the recruitment of specific mRNAs to the complex, which allows for the efficient translation of these mRNAs into the cytoplasm. The AP2 adapter complex also plays a critical role in the regulation of protein stability, by affecting the levels of protein synthesis and degradation.

The AP2 adapter complex is a well-established drug target, with several studies having identified potential inhibitors that can modulate the activity of the complex. These inhibitors have been shown to have a range of therapeutic effects, including the inhibition of cancer cell growth, the treatment of neurodegenerative diseases, and the modulation of immune cell function.

In addition to its potential therapeutic applications, the AP2 adapter complex is also a valuable biomarker for the study of protein synthesis and regulation. The complex is highly reproducible, which allows for the use of high-throughput assays to study its properties. Additionally, the AP2 adapter complex is well-characterized, with a large number of studies characterizing its various subunits and their interactions.

Overall, the AP2 adapter complex is a complex protein that plays a critical role in the regulation of protein synthesis in eukaryotic cells. Its regulation of protein stability and translation of specific mRNAs makes it a valuable target for the development of new drugs and therapies. Further research is needed to fully understand the mechanisms of its regulation and its potential therapeutic applications.

Protein Name: Adaptor-related Protein Complex 2

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