TLLs: Versatile Drug Targets and Biomarkers (P47029)

Target Name: Tolloid-like protein

NCBI ID: P47029

Other Name(s): TLL

TLLs: Versatile Drug Targets and Biomarkers

Tolloid-like protein (TLL) is a protein that is expressed in many tissues throughout the body. It is a member of the superfamily of transmembrane protein and is characterized by the presence of a toll-like receptor (TLR) domain. TLLs are involved in various physiological processes in the body, including inflammation, immune response, and cell signaling.

One of the unique features of TLLs is their ability to form a covalent complex with a variety of molecules, including drugs and toxins. This ability makes them an attractive drug target for researchers and pharmaceutical companies. In fact, there are currently several TLL-based drugs in development, targeting different signaling pathways and cellular processes.

One of the most well-known TLLs is TLR-4, which is expressed in many different tissues throughout the body, including the lungs, spleen, heart, kidneys, and brain. TLR-4 is involved in various signaling pathways, including the production of reactive oxygen species (ROS) and the regulation of inflammation. It is also involved in the immune response, cell signaling, and tissue repair.

TLLs have also been shown to play a key role in the development and progression of various diseases, including cancer. For example, TLL-1 has been shown to promote the growth and survival of cancer cells, while TLL-3 has been shown to contribute to the development of colon cancer.

In addition to its role in disease, TLLs are also of interest as potential biomarkers. Their ability to form a covalent complex with a variety of molecules makes them useful for the detection and quantification of these molecules in biological samples. This makes them an attractive option for the development of diagnostic tools and diagnostic tests.

Overall, TLLs are a promising drug target and biomarker due to their ability to form covalent complexes, their involvement in various signaling pathways, and their involvement in the development and progression of diseases. As research continues to advance, it is likely that the role of TLLs in biology will become increasingly important, and new treatments and diagnostic tools will be developed.

Protein Name: Tolloid-like Protein (nonspecified Subtype)

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