HAX1: A Potential Drug Target and Biomarker for ALS-like Neurodegenerative Diseases

Target Name: HAX1

NCBI ID: G10456

HAX1: A Potential Drug Target and Biomarker for ALS-like Neurodegenerative Diseases

Introduction

Several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), are characterized by the progressive loss of motor neurons and other central nervous system (CNS) cells. These conditions can significantly impact an individual's quality of life and even their life expectancy. Although several treatments have been developed to manage these diseases, the lack of effective therapies remains a significant unmet medical need.

The HCLSBP1 gene, located on chromosome 18q21, has been identified as a potential drug target and biomarker for ALS-like neurodegenerative diseases. The HCLSBP1 gene encodes a protein known as HCLSBP1, which is involved in the regulation of cellular processes essential for neuronal survival and function. Several studies have suggested that HCLSBP1 plays a crucial role in the development and progression of ALS-like neurodegenerative diseases.

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Protein Name: HCLS1 Associated Protein X-1

Functions: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools

More Common Targets