HCG11: A Protein Involved in Immune Response and Cancer (G493812)

Target Name: HCG11

NCBI ID: G493812

Other Name(s): HLA complex group 11 | bK14H9.3 | CTA-14H9.3

HCG11: A Protein Involved in Immune Response and Cancer

HCG11 is a protein that is expressed in various tissues throughout the body, including the liver, spleen, and Peyer's patches of the small intestine. It is a member of the HLA complex group 11, which is a subclass of the major histocompatibility complex (MHC). The MHC is a protein that is found on the surface of most human cells and is responsible for presenting antigens to T cells.

HCG11 is a 24-kDa protein that is composed of 11 constant and 11 variable regions. The variable regions of HCG11 contain the majority of the protein's surface antigens, including a 63-kDa伪 chain and a 61-kDa尾 chain. The 伪 chain consists of a variable region that contains the protein's most important functional domains, including a 150-amino acid long terminal repeats region and a 6-amino acid C-terminal region that is involved in interactions with other proteins. The 尾 chain is a constant region that contains the protein's secondary structure, including a 24-amino acid N-terminal region and a 68-amino acid C-terminal region.

HCG11 is expressed in a variety of tissues and is involved in the immune response, cell adhesion, and tissue homeostasis. It is highly expressed in the liver and spleen, and is also found in the Peyer's patches of the small intestine, where it is involved in the immune response to pathogens.

One potential drug target for HCG11 is the use of small molecule inhibitors to prevent or reverse its function in cancer cells.HCG11 has been shown to be involved in the development and progression of several types of cancer, including colon cancer, gastric cancer, and liver cancer. Therefore, inhibitors of HCG11 have been shown to be effective in treating these cancers.

Another potential drug target for HCG11 is the use of antibodies to target the protein itself and enhance the immune response against cancer cells. Studies have shown that antibodies against HCG11 can enhance the activity of natural killer cells (NK cells) and T cells, which are important immune cells that play a key role in fighting cancer.

HCG11 is also a potential biomarker for cancer, as its expression levels can be increased in response to cancerous changes in the body. Therefore, measuring HCG11 levels in cancer samples or body fluids may be a useful diagnostic tool for cancer diagnosis and monitoring.

In conclusion, HCG11 is a protein that is expressed in various tissues throughout the body and is involved in the immune response, cell adhesion, and tissue homeostasis. It is a potential drug target for cancer and a potential biomarker for cancer. Further research is needed to fully understand the role of HCG11 in the immune response and its potential as a drug or biomarker.

Protein Name: HLA Complex Group 11

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