HELQ: A Potential Drug Target for Cancer (G113510)

Target Name: HELQ

NCBI ID: G113510

HELQ: A Potential Drug Target for Cancer

HeLa cells, commonly used in cell culture, have been a popular resource for researchers to study the human immune response. Among the many proteins that have been identified in these cells, one of particular interest is HELQ (DNA helicase HEL308). This protein, also known as HDAC11, plays a crucial role in the regulation of DNA replication and has been linked to a number of diseases, including cancer.

HELQ is a member of the DNA-protein complex known as the nucleosome. The nucleosome is the basic unit of DNA replication and is composed of a core of DNA, a protein called histone H1, and a smaller protein called microtubule protein 2 (MT2). HELQ is responsible for breaking down the DNA double helix and creating single-stranded ends, which allows for the formation of a nucleosome.

HELQ's role in DNA replication is just one of many important functions it performs. The protein is also involved in the regulation of gene expression, cell division, and DNA repair. In addition, HELQ has been shown to play a key role in the development and progression of cancer.

Studies have suggested that HELQ may be a potential drug target or biomarker for a number of diseases, including cancer. For example, studies have shown that inhibiting HELQ has anti-cancer effects in cell cultures and animal models of cancer. In addition, HELQ has been shown to be overexpressed in a number of cancer types, which suggests that targeting the protein may be a promising strategy for cancer treatment.

The discovery and characterization of HELQ also has the potential to shed light on the underlying mechanisms of many diseases. For example, the regulation of DNA replication is a critical process that is affected by a wide range of factors, including DNA damage, aging, and cancer. By studying the role of HELQ in this process, researchers may be able to identify new targets for cancer and other diseases.

In conclusion, HELQ is a protein that plays a crucial role in the regulation of DNA replication and has been linked to a number of diseases, including cancer. The protein's role in this process makes it an attractive target for drug development and research into the underlying mechanisms of these diseases. Further studies are needed to fully understand the functions of HELQ and its potential as a drug or biomarker.

Protein Name: Helicase, POLQ Like

Functions: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:11751861, PubMed:19995904, PubMed:21398521, PubMed:24005041, PubMed:24005565, PubMed:34316696, PubMed:34937945). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (PubMed:34937945). Possesses both DNA unwinding and annealing activities (PubMed:34937945). Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA (PubMed:34937945). Efficiently unwinds substrates containing 3' overhangs or a D-loop (PubMed:21398521, PubMed:34937945). In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing (PubMed:34937945). Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences (PubMed:34316696, PubMed:34937945)

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