HECW1: A Protein Involved in Protein Degradation and Cell Signaling
HECW1: A Protein Involved in Protein Degradation and Cell Signaling
HECW1 (E3 ubiquitin-protein ligase HECW1 (isoform b)) is a protein that plays a crucial role in the regulation of protein degradation in eukaryotic cells. It is a member of the HECW1 family of ubiquitin-protein ligases, which are known for their ability to remove ubiquitin from target proteins. This process is essential for protein homeostasis and for the regulation of a wide range of cellular processes, including cell growth, differentiation, and stress responses.
HECW1 is a 176 amino acid protein that is expressed in most tissues of the body. It is primarily localized to the endoplasmic reticulum (ER), where it is involved in the degradation of a wide range of proteins. HECW1 is also known for its ability to interact with the protein degradation regulator, known as the NEDD8-like domain (NEDD8-like), which is a conserved protein that is involved in the degradation of various cellular proteins.
HECW1 functions by forming a covalent complex with its target protein and then using a NEDD8-like domain to add a ubiquitin tag to the protein. This ubiquitin tag is attached to a specific lysine residue on the target protein, which marks it for degradation. HECW1 is also known for its ability to modulate the stability of its target proteins by altering their ubiquitin levels.
HECW1 is widely expressed in many organisms, including humans. It is involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and stress responses. For example, HECW1 is involved in the regulation of cell adhesion, as it has been shown to play a role in the degradation of cell-adhesion molecules such as cadherins and tight junctions.
In addition to its role in cell signaling, HECW1 is also a potential drug target. Its ability to modulate the stability of target proteins makes it an attractive target for small molecules that can inhibit its activity. This has led to a great deal of interest in the development of compounds that can specifically target HECW1 and modulate its activity.
One of the challenges in studying HECW1 is its high stability, as it is difficult to overexpress the protein in cells and then study its function. To overcome this challenge, researchers have developed a number of techniques for study, including biochemical assays, cell-based assays, and in vitro assays. These techniques have allowed researchers to study the behavior of HECW1 in a variety of cellular contexts and to determine its function in a wide range of cellular processes.
In conclusion, HECW1 is a protein that plays a crucial role in the regulation of protein degradation in eukaryotic cells. Its ability to remove ubiquitin from target proteins makes it an attractive target for small molecules that can inhibit its activity. Further research is needed to fully understand the function of HECW1 and to develop effective compounds that can specifically target it.
Protein Name: HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 1
Functions: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS
More Common Targets
HECW2 | Hedgehog Protein | HEG1 | HEIH | HELB | HELLS | HELQ | HELT | HELZ | HELZ2 | Heme Oxygenase (HO) | HEMGN | HEMK1 | Hemoglobin A-2 (HbA-2) | Hemoglobulin A (HbA) | HENMT1 | HEPACAM | HEPACAM2 | HEPH | HEPHL1 | HEPN1 | HER (erbB) | HERC1 | HERC2 | HERC2P10 | HERC2P2 | HERC2P3 | HERC2P4 | HERC2P5 | HERC2P7 | HERC2P8 | HERC2P9 | HERC3 | HERC4 | HERC5 | HERC6 | HERPUD1 | HERPUD2 | HES1 | HES2 | HES3 | HES4 | HES5 | HES6 | HES7 | HESX1 | Heterogeneous nuclear ribonucleoprotein complex | HEXA | HEXA-AS1 | HEXB | HEXD | HEXIM1 | HEXIM2 | Hexokinase | HEY1 | HEY2 | HEY2-AS1 | HEYL | HFE | HFM1 | HGC6.3 | HGD | HGF | HGFAC | HGH1 | HGS | HGSNAT | HHAT | HHATL | HHEX | HHIP | HHIP-AS1 | HHIPL1 | HHIPL2 | HHLA1 | HHLA2 | HHLA3 | HIBADH | HIBCH | HIC1 | HIC2 | HID1 | HID1-AS1 | HIF1A | HIF1A-AS1 | HIF1A-AS2 | HIF1A-AS3 | HIF1AN | HIF3A | HIGD1A | HIGD1AP1 | HIGD1AP10 | HIGD1B | HIGD1C | HIGD2A | HIGD2B | High affinity cAMP-specif | High Affinity Immunoglobulin Epsilon Fc Receptor | HIKESHI | HILPDA