HDAC4: Key Enzyme in The HDAC Pathway (G9759)

Target Name: HDAC4

NCBI ID: G9759

HDAC4: Key Enzyme in The HDAC Pathway

Histone deacetylase 4 (HDAC4) is a protein that is expressed in almost all human tissues and plays a crucial role in the regulation of cellular processes. It is a key enzyme in the histone deacetylation (HDAC) pathway, which is a process that is involved in the regulation of gene expression and the maintenance of tissue homeostasis.

The HDAC pathway is a complex series of enzymes that remove acetyl groups from histones, which are small proteins that make up the nucleosome, the basic unit of DNA in the cell. The removal of acetyl groups from histones is critical for the regulation of DNA- protein interactions, and is involved in a wide range of cellular processes, including the control of cell growth, differentiation, and response to environmental stimuli.

HDAC4 is one of the key enzymes in the HDAC pathway, and is involved in the removal of acetyl groups from histones. It is a 21-kDa protein that is expressed in a variety of tissues, including muscle, pancreas, and brain. It is primarily localized to the nuclei of cells, and is involved in the regulation of gene expression and the maintenance of tissue homeostasis.

One of the key functions of HDAC4 is its role in the regulation of cell growth and differentiation. HDAC4 is involved in the regulation of cell proliferation, and is required for the growth and development of tissues. In addition, HDAC4 is also involved in the regulation of cell differentiation, and is required for the formation of normal tissues and organs.

HDAC4 is also involved in the regulation of cellular response to environmental stimuli. It is involved in the regulation of cellular signaling pathways that are involved in stress response, and is required for the regulation of cell survival in response to environmental stimuli.

In addition to its role in the regulation of cell growth and differentiation, HDAC4 is also involved in the regulation of cellular signaling pathways that are involved in cell survival. It is involved in the regulation of cell signaling pathways that are involved in stress response, and is required for the regulation of cell survival in response to environmental stimuli.

HDAC4 is also involved in the regulation of gene expression, and is required for the normal regulation of gene expression in a variety of tissues. It is involved in the regulation of gene expression by the DNA-protein complex, and is required for the normal function ofgene

Protein Name: Histone Deacetylase 4

Functions: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256)

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