Understanding MRPL3: A Potential Drug Target Or Biomarker (G11222)

Target Name: MRPL3

NCBI ID: G11222

Understanding MRPL3: A Potential Drug Target Or Biomarker

MRPL3 (MutL-cullin 3) is a protein that is expressed in various tissues of the body, including the brain, spleen, and peripheral blood cells. It is a member of the MUTL (MutL) family of proteins, which are known for their role in regulating DNA double-strand break repair. MRPL3 is unique among MUTL proteins in that it is expressed in a variety of cell types, making it a potential drug target or biomarker.

The MUTL family of proteins was identified in the late 1990s based on the observation that many proteins contain conserved motifs that are involved in DNA repair. These motifs are known as \" MutL-considerations\" and are used to recruit MUTL proteins to their DNA repair activities. The MUTL family includes a number of well-studied proteins, including MRPL1, MRPL2, and MRPL3.

MRPL3 is a 166 amino acid protein that is expressed in a variety of tissues, including the brain, spleen, and peripheral blood cells. It is a member of the MUTL family of proteins and is characterized by the presence of several conserved motifs, including a double-strand break repair domain and a unique N-terminal region that is involved in protein-protein interactions.

The double-strand break repair domain is a critical region of the MUTL family of proteins that is involved in repairing double-strand breaks in DNA. This region is composed of several conserved motifs, including a critical alpha-helices that are involved in the formation of a stable complex with the double-strand break repair enzyme, DNAA1. In addition to the double-strand break repair domain, MRPL3 also contains several other regions that are involved in protein-protein interactions, including a N-terminal region that is involved in interactions with the protein JNJ212665 and a C-terminal region that is involved in interactions with the protein CoR1981.

The N-terminal region of MRPL3 is a unique region that is involved in protein-protein interactions. This region contains several conserved motifs, including a critical alpha-helices that is involved in the formation of a stable complex with the protein JNJ212665. This interaction between MRPL3 and JNJ212665 is important for the regulation of DNA double-strand break repair and may be a potential drug target or biomarker.

The C-terminal region of MRPL3 is also a unique region that is involved in protein-protein interactions. This region contains several conserved motifs, including a critical alpha-helices that is involved in the formation of a stable complex with the protein CoR1981. This interaction between MRPL3 and CoR1981 is important for the regulation of DNA double-strand break repair and may be a potential drug target or biomarker.

In conclusion, MRPL3 is a unique and conserved protein that is expressed in various tissues of the body. It is a member of the MUTL family of proteins and is characterized by the presence of several conserved motifs, including a double-strand break repair domain and a unique N-terminal and C-terminal region that is involved in protein-protein interactions. These features make MRPL3 a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of MRPL3 in DNA double-strand break repair and to develop effective treatments for these diseases.

Protein Name: Mitochondrial Ribosomal Protein L3

More Common Targets