CARMIL2: A Potential Drug Target and Biomarker (G146206)

Target Name: CARMIL2

NCBI ID: G146206

CARMIL2: A Potential Drug Target and Biomarker

CARMIL2 (C-terminal repeat, lysine-rich repeat, tropomodulin and proline-rich containing protein) is a protein found on cell membranes. It plays an important role in cell signal transduction and intracellular transport. In recent years, researchers have conducted in-depth studies on the function of CARMIL2 and found that it may be a potential drug target or biomarker.

Structure of CARMIL2

CARMIL2 is a characteristic protein that consists of four subunits on the cell membrane, including an N-terminal 伪-helix, a central 尾-sheet, and a C-terminal domain. Each subunit contains a specific functional domain. For example, the N-terminal 伪-helix can bind intracellular signaling molecules, the central 尾-sheet structure can form ion channels, and the C-terminal domain can interact with the cytoskeleton. effect.

CARMIL2 features

CARMIL2 plays an important role in cell signaling and intracellular trafficking. In neurons, CARMIL2 is involved in many signal transduction pathways, such as calcium ion signaling and neurotransmitter signaling. In endocrine cells, CARMIL2 is involved in many hormone signaling pathways, such as thyroid hormone signaling. In addition, CARMIL2 can also participate in intracellular transport, such as glucose transport and amino acid transport.

Pharmacological significance of CARMIL2

Because CARMIL2 plays an important role in cell signal transduction and intracellular trafficking, it is considered a potential drug target. Recently, researchers found that CARMIL2 inhibitors inhibit tumor growth in neuronal and endocrine cells. In addition, CARMIL2 inhibitors may reduce symptoms of diseases such as diabetic retinopathy and Alzheimer's disease.

Biological significance of CARMIL2

The discovery and functional study of CARMIL2 has important implications for understanding important mechanisms of cell signaling and intracellular trafficking. it

Protein Name: Capping Protein Regulator And Myosin 1 Linker 2

Functions: Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647349, PubMed:27647348, PubMed:28112205)

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