CST4: A Potential Drug Target and Biomarker for Cancer and Spasticity

Target Name: CST4

NCBI ID: G1472

CST4: A Potential Drug Target and Biomarker for Cancer and Spasticity

CST4 (Cystatin 4) is a protein that is expressed in various tissues throughout the body, including the liver, pancreas, and blood cells. It is a member of the cystatin family, which includes proteins that are known for their ability to remove foreign particles from cells.

One of the unique features of CST4 is its ability to interact with the drug drug ipratropium bromide (IPB), which is used to treat spasticity and other muscle-related conditions. IPB works by blocking the action of a protein called GABA, which is involved in the regulation of muscle contractions. By blocking the action of GABA, IPB can cause muscle relaxation, which can be useful for treating spasticity and other muscle-related conditions.

CST4 has also been shown to play a role in the regulation of inflammation in the body. Many diseases, including cancer, are associated with chronic inflammation, and CST4 has been shown to be involved in the regulation of this process.

One of the potential benefits of targeting CST4 as a drug target is its potential to treat a wide range of diseases, including cancer, spasticity, and autoimmune disorders. CST4 has also been shown to be involved in the regulation of many different signaling pathways, which makes it an attractive target for researchers to investigate.

In addition to its potential as a drug target, CST4 has also been shown to be a useful biomarker for a number of different diseases. For example, CST4 has been shown to be elevated in the blood of people with pancreatic cancer, and it has been used as a biomarker for tracking the effectiveness of ipratropium bromide in treating spasticity.

Overall, CST4 is a protein that has the potential to be a drug target or biomarker for a wide range of diseases. Further research is needed to fully understand its role in the regulation of muscle and immune systems, and to determine its potential as a therapeutic agent.

Protein Name: Cystatin S

Functions: This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively

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