CTDSPL: A Protein Regulating Protein-Protein Interactions (G10217)

Target Name: CTDSPL

NCBI ID: G10217

CTDSPL: A Protein Regulating Protein-Protein Interactions

CTD small phosphatase-like protein (CTDSPL) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and muscle. It is a member of the protein family of small phosphatases, which are known for their ability to regulate protein-protein interactions and play a role in cellular signaling.

One of the unique features of CTDSPL is its ability to interact with other proteins that contain multiple phosphate groups. This interaction is critical for the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism.

Research has suggested that CTDSPL may have potential as a drug target or biomarker. For example, some studies have shown that inhibiting CTDSPL activity can lead to the inhibition of various cellular processes that are important for cancer growth and progression. Additionally, some researchers have found that high levels of CTDSPL are associated with various diseases, including heart disease and neurological disorders.

Another potential mechanism by which CTDSPL may be targeted as a drug or biomarker is its role in cellular signaling. CTDSPL is a key regulator of the protein-protein interaction known as the protein-tyrosine phosphate (PTP) system. This system is involved in the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism.

Inhibiting the activity of CTDSPL or its interaction with other proteins involved in the PTP system may be a useful way to treat various diseases. For example, some researchers have shown that inhibiting the activity of CTDSPL can lead to the inhibition of cellular signaling processes that are important for cancer growth and progression. Additionally, some studies have suggested that high levels of CTDSPL may be associated with various diseases, including heart disease and neurological disorders.

In conclusion, CTD small phosphatase-like protein is a protein that is expressed in various tissues throughout the body and is involved in the regulation of protein-protein interactions. Its unique ability to interact with other proteins that contain multiple phosphate groups makes it a potential drug target or biomarker. Further research is needed to fully understand the role of CTDSPL in cellular signaling and its potential as a drug or biomarker.

Protein Name: CTD Small Phosphatase Like

Functions: Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation

More Common Targets