CUL7: A Potential Drug Target and Biomarker for Diseases (G9820)

Target Name: CUL7

NCBI ID: G9820

CUL7: A Potential Drug Target and Biomarker for Diseases

CUL7, short for cyclin D-like gene 7, is a gene that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The CUL7 gene is a member of the cyclin gene family, which is known for regulating cell cycle progression in eukaryotic cells. Cyclins are composed of a variable number of repetitive subunits, and each subunit contains a domain that is responsible for binding to specific DNA sequences. The CUL7 gene contains seven repetitive subunits and is located on chromosome 16p1.2 in the nucleus.

CUL7 has been shown to be involved in various cellular processes, including cell division, apoptosis, and autophagy. It has also been implicated in the development and progression of various diseases.

One of the most promising aspects of CUL7 is its potential as a drug target. Researchers have identified several potential drug candidates that target CUL7, including small molecules, peptides, and antibodies. These compounds have been shown to inhibit the activity of CUL7 and to induce cell death, cell cycle arrest, and apoptosis in cancer cells.

In addition to its potential as a drug target, CUL7 has also been identified as a potential biomarker for various diseases. Its expression has been shown to be elevated in a variety of cancer types, including breast, ovarian, and colorectal cancers. It has also been shown to be elevated in the brains of individuals with neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases.

CUL7 is also known as cyclin D-like gene 7 because it is part of the cyclin D gene family, which includes several other genes, including cyclin D1, cyclin D2, and cyclin D3. These genes are involved in regulating cell cycle progression and have been implicated in the development and progression of various diseases.

In conclusion, CUL7 is a gene that has the potential to be a drug target or biomarker for various diseases. Its expression has been shown to be involved in various cellular processes, including cell division, apoptosis, and autophagy, and its potential as a drug target is based on the identification of several potential compounds that target CUL7. Its potential as a biomarker is based on its expression being elevated in various diseases, including cancer and neurodegenerative diseases. Further research is needed to fully understand the role of CUL7 in diseases and to develop effective treatments.

Protein Name: Cullin 7

Functions: Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions

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