CUEDC2: A Potential Drug Target and Biomarker (G79004)

Target Name: CUEDC2

NCBI ID: G79004

Other Name(s): CUE domain-containing protein 2 | C10orf66 | CUE domain containing 2 | CUED2_HUMAN | bA18I14.5

CUEDC2: A Potential Drug Target and Biomarker

Introduction

CUEDC2 (CUE domain-containing protein 2) is a protein that has been identified as a potential drug target and biomarker. It is a member of the superfamily of N-cadherinrelated proteins, which are involved in cell-cell adhesion and survival signaling. CUEDC2 is expressed in a variety of tissues and has been shown to play a role in several cellular processes, including cell signaling, migration, and invasion.

Drug Target Potential

CUEDC2 has been identified as a potential drug target due to its unique structure and its involvement in several cellular processes. One of the key factors that make CUEDC2 an attractive drug target is its ability to interact with several different protein tyrosine kinases (PTKs), including PD-L1, T-cell receptor (TCR), and heat shock protein (HSP70). These interactions make CUEDC2 a potential target for small molecules that can inhibit the activity of these PTKs.

In addition to its potential interactions with PTKs, CUEDC2 has also been shown to play a role in several cellular signaling pathways that are involved in cancer progression. For example, CUEDC2 has been shown to be involved in the regulation of the Notch signaling pathway, which is involved in the development and progression of many types of cancer.

Biomarker Potential

CUEDC2 has also been identified as a potential biomarker for several types of cancer, including breast, ovarian, and colorectal cancer. This is because CUEDC2 has been shown to be expressed in these types of cancer cells and has been shown to play a role in their growth and survival. In addition, CUEDC2 has been shown to be involved in the regulation of several cellular processes that are commonly associated with cancer, including cell cycle progression, apoptosis (programmed cell death), and angiogenesis (the formation of new blood vessels).

Conclusion

In conclusion, CUEDC2 is a protein that has been identified as a potential drug target and biomarker. Its unique structure and its involvement in several cellular processes make it an attractive target for small molecules that can inhibit its activity. Additionally, CUEDC2 has also been shown to play a role in several cellular signaling pathways that are involved in cancer progression, making it a potential biomarker for several types of cancer. Further research is needed to determine the full potential of CUEDC2 as a drug target and biomarker.

Protein Name: CUE Domain Containing 2

Functions: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism

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