COMMD1: A Potential Drug Target and Biomarker (G150684)

Target Name: COMMD1

NCBI ID: G150684

COMMD1: A Potential Drug Target and Biomarker

COMMD1, also known as protein Murr1, is a protein that is expressed in many different tissues throughout the body. It is a member of the Murr protein family, which is known for their role in cell signaling and development. In this article, we will discuss the research on COMMD1 and its potential as a drug target or biomarker.

COMMD1 was first identified in the 1990s as a protein that was expressed in a wide range of tissues, including brain, heart, and muscle. It is a small protein that has four known functions:

1. Regulation of cell signaling pathways: COMMD1 has been shown to regulate the signaling pathways that are involved in cell growth, differentiation, and survival. It has been shown to play a role in the regulation of the Wnt signaling pathway, which is involved in the development and maintenance of tissues.
2. Cell adhesion: COMMD1 is involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs.
3. Cell survival: COMMD1 has been shown to play a role in the regulation of cell survival, which is the process by which cells live and die.
4. Cell proliferation: COMMD1 is involved in the regulation of cell proliferation, which is the process by which cells grow and divide.

COMMD1 has also been shown to play a role in the regulation of various cellular processes, including cell migration, angiogenesis, and inflammation. It is also involved in the regulation of cellular signaling pathways that are involved in cell growth, differentiation, and the development of tissues.

In addition to its role in cell signaling, COMMD1 has also been shown to be involved in the regulation of cellular processes that are important for tissue development and homeostasis. For example, it has been shown to play a role in the regulation of the formation of blood vessels, which is important for maintaining tissue oxygenation and glucose availability.

COMMD1 has also been shown to be involved in the regulation of cellular processes that are important for the development and maintenance of tissues. For example, it has been shown to play a role in the regulation of the formation of new neurons, which is important for the development of the nervous system.

In conclusion, COMMD1 is a protein that is involved in a wide range of cellular processes that are important for tissue development and homeostasis. Its functions as a regulator of cell signaling pathways, cell adhesion, cell survival, and cell proliferation make it an attractive target for drug development. Additionally, its role in the regulation of tissue development and homeostasis makes it a valuable biomarker for the diagnosis and treatment of various diseases.

COMMD1 has been shown to play a role in the regulation of cellular processes that are important for the development and maintenance of tissues. Its functions as a regulator of cell signaling pathways, cell adhesion, cell survival, and cell proliferation make it an attractive target for drug development. Additionally, its role in the regulation of tissue development and homeostasis makes it a valuable biomarker for the diagnosis and treatment of various diseases.

COMMD1 is a protein that has been shown to play a role in the regulation of various cellular processes that are important for tissue development and homeostasis. Its functions as a regulator of cell signaling pathways, cell adhesion, cell survival, and cell proliferation make it an attractive target for drug development. Additionally, its role in the regulation of tissue development and homeostasis makes it a valuable biomarker for the diagnosis and treatment of various diseases.

Protein Name: Copper Metabolism Domain Containing 1

Functions: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141). Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner (PubMed:28604741)

More Common Targets