CYP51A1: Key Regulator of Cellular Processes (G1595)

Target Name: CYP51A1

NCBI ID: G1595

CYP51A1: Key Regulator of Cellular Processes

CYP51A1, also known as CYP51, is a gene that encodes a protein known as CYP51A1. This protein is a key regulator of the synthesis of many different compounds, including drugs, toxins, and other substances that are produced by the body. It is found in most and tissues cells in the body and is responsible for catalyzing the metabolism of these substances.

One of the key functions of CYP51A1 is its role in drug metabolism. Many drugs are metabolized by CYP51A1, and the rate at which they are metabolized can have a significant impact on their effectiveness and safety. For example, the metabolite of the drug Atorvastatin, which is used to lower cholesterol levels, is metabolized by CYP51A1 and is inactivated as a result. Similarly, the metabolite of the drug warfarin, which is used to prevent blood clots, is also metabolized by CYP51A1 and is inactivated.

In addition to its role in drug metabolism, CYP51A1 is also involved in the metabolism of other substances that are not drugs. For example, it is involved in the metabolism of steroids, which are used to treat a variety of conditions, and in the of toxins, which are released by bacteria and other microorganisms.

CYP51A1 is also involved in the regulation of cellular processes. For example, it is involved in the synthesis of many important cell components, such as collagen, which is a protein that makes up the extracellular matrix of cells. regulation of cell signaling pathways, which are responsible for transmitting signals from cells to other cells and for controlling the behavior of cells.

CYP51A1 is a gene that plays a critical role in many different cellular processes in the body. It is involved in the regulation of drug metabolism, cellular signaling pathways, and the synthesis of important cell components. As a result, it is an attractive target for drug developers and researchers who are interested in understanding and manipulating the activity of this gene.

Protein Name: Cytochrome P450 Family 51 Subfamily A Member 1

Functions: Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis (PubMed:8619637, PubMed:9559662, PubMed:20149798). Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis (PubMed:8619637, PubMed:9559662, PubMed:20149798). Can also demethylate susbtrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL (PubMed:9559662)

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