RNF213-AS1: A Drug Target / Disease Biomarker (G100294362)

Target Name: RNF213-AS1

NCBI ID: G100294362

Other Name(s): RNF213 antisense RNA 1

RNF213-AS1: A Drug Target / Disease Biomarker

RNA-F Active Site 213 (AS1) is a non-coding RNA molecule that plays a critical role in various cellular processes. It is a key player in the RNA-F family of proteins, which are involved in the regulation of gene expression. RNA-FAS1 is a 21-kDa protein that contains a single RNA domain and is expressed in various cell types.

One of the unique features of RNA-FAS1 is its ability to interact with specific DNA sequences. This interaction is mediated by the protein's C-terminus, which contains a conservedGACAAT motif. This motif is known to be involved in the formation of RNA-FAS1-DNA hybrids, which are stable and can interact with transcription factors to regulate gene expression.

RNA-FAS1 is also known for its role in regulating gene expression. It has been shown to play a negative role in the regulation of gene expression by RNA-FAS1, by binding to specific RNA-FAS1-targeting proteins and repressing their activity. This interaction between RNA-FAS1 and RNA-FAS1-targeting proteins is critical for the regulation of gene expression and is a potential drug target.

Another unique feature of RNA-FAS1 is its ability to form a protein-protein interaction. This interaction occurs between the C-terminus of RNA-FAS1 and the N-terminus of another protein called AS1. This interaction is known as the N-end rule, and it is a mechanism by which RNA-FAS1 can interact with other proteins and regulate their activity.

RNA-FAS1 has also been shown to play a role in the regulation of cellular processes such as cell growth, apoptosis, and autophagy. It has been shown to play a positive role in the regulation of cell growth by inhibiting the activity of the protein kinase PDK4, which is involved in cell growth and survival. RNA-FAS1 has also been shown to play a negative role in the regulation of apoptosis, by interacting with the protein Bcl-2 and preventing its activity from promoting apoptosis.

In conclusion, RNA-FAS1 is a non-coding RNA molecule that plays a critical role in various cellular processes. Its unique ability to interact with specific DNA sequences and form protein-protein interactions makes it a potential drug target. The regulation of gene expression by RNA-FAS1 is a critical process that is involved in the regulation of cellular processes such as cell growth, apoptosis, and autophagy. Further research is needed to fully understand the role of RNA-FAS1 in these processes and to develop potential therapeutic strategies.

Protein Name: RNF213 Antisense RNA 1

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